Document Detail

Adjunctive effect of hyperbaric oxygen treatment after thrombolysis on left ventricular function in patients with acute myocardial infarction.
MedLine Citation:
PMID:  15459609     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of hyperbaric oxygen in patients with acute myocardial infarction is controversial, ranging from not beneficial to having a favorable effect. This randomized study was conducted to further assess the benefit of hyperbaric oxygen treatment after thrombolysis on left ventricular function and remodeling in patients with acute myocardial infarction. METHODS: Seventy-four consecutive patients with first acute myocardial infarction were randomly assigned to treatment with hyperbaric oxygen treatment combined with streptokinase (HBO+) or streptokinase alone (HBO-). RESULTS: There was a significant decrease of end-systolic volume index from the first day to the third week in HBO+ patients compared with HBO- patients (from 30.40 to 28.18 vs from 30.89 to 36.68 mL/m2, P <.05) accompanied with no changes of end-diastolic volume index in HBO+ compared with increased values in HBO- (from 55.68 to 55.10 vs from 55.87 to 63.82 mL/m2, P <.05). Ejection fraction significantly improved in the HBO+ group and decreased in the HBO- group of patients after 3 weeks of acute myocardial infarction (from 46.27% to 50.81% vs from 45.54% to 44.05 %, P <.05). CONCLUSIONS: Adjunctive hyperbaric oxygen therapy after thrombolysis in acute myocardial infarction has a favorable effect on left ventricular systolic function and the remodeling process.
Milica Dekleva; Aleksandar Neskovic; Alja Vlahovic; Biljana Putnikovic; Branko Beleslin; Miodrag Ostojic
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American heart journal     Volume:  148     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-01     Completed Date:  2005-01-25     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E14     Citation Subset:  AIM; IM    
Clinical Medical Center Dr Dradisa Misovic-Dedinje, Department of Echocardiography, Belgrade, Serbia and Montenegro, Yugoslavia. mildek@eunet.yu
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MeSH Terms
Combined Modality Therapy
Creatine Kinase / blood
Fibrinolytic Agents / therapeutic use*
Hyperbaric Oxygenation*
Middle Aged
Myocardial Infarction / physiopathology,  therapy*,  ultrasonography
Streptokinase / therapeutic use*
Stroke Volume
Thrombolytic Therapy
Ventricular Function, Left*
Ventricular Remodeling
Reg. No./Substance:
0/Fibrinolytic Agents; EC Kinase; EC 3.4.-/Streptokinase

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