Document Detail

Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT.
MedLine Citation:
PMID:  22093005     Owner:  NLM     Status:  MEDLINE    
AIM: A double-blind randomized controlled trial to determine whether dietary supplementation with fruit/vegetable/berry juice powder concentrates, simultaneously with non-surgical periodontal therapy, improved 2-month treatment outcomes.
METHODS: Volunteers with chronic periodontitis were randomly assigned to one of three groups: fruit/vegetable (FV), fruit/vegetable/berry (FVB) or placebo. Supplements were taken daily during non-surgical debridement and maintenance and outcomes assessed at 2, 5 and 8 months after completion. Primary outcomes were mean probing pocket depth (PPD), clinical attachment gain, % sites bleeding on probing (% BOP) at 2 months. Adherence and plasma β-carotene were determined.
RESULTS: Sixty-one nutritionally replete (by serum biochemistry) volunteers enrolled and 60 (n = 20 per arm) completed the 2-month review. Clinical outcomes improved in all groups at 2 months, with additional improvement in PPD versus placebo for FV (p < 0.03). Gingival crevicular fluid volumes diminished more in supplement groups than placebo (FVB; p < 0.05) at 2 months, but not at later times. The % BOP (5 months) and cumulative plaque scores (8 months) were lowered more in the FV group (p < 0.05).
CONCLUSIONS: Adjunctive juice powder concentrates appear to improve initial pocket depth reductions in nutritionally replete patients, where plasma micronutrient bioavailability is attainable. Definitive multicentre studies in untreated and treated patients are required to ascertain the clinical significance of such changes.
Iain L C Chapple; Michael R Milward; Nicola Ling-Mountford; Paul Weston; Kevin Carter; Keeley Askey; Gerard E Dallal; Silke De Spirt; Helmut Sies; Dina Patel; John B Matthews
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-10-17
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  39     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-05-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  62-72     Citation Subset:  D; IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, UK.
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MeSH Terms
Antioxidants / administration & dosage*
Dental Prophylaxis*
Dietary Supplements*
Double-Blind Method
Micronutrients / administration & dosage*
Middle Aged
Periodontitis / therapy*
Phytotherapy / methods
Plant Preparations / administration & dosage*
Plants, Edible
Treatment Outcome
Reg. No./Substance:
0/Antioxidants; 0/Micronutrients; 0/Plant Preparations

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