| Adjunct therapeutic plasma exchange for anti-N-methyl-D-aspartate receptor antibody encephalitis: a case report and review of literature. | |
| | |
MedLine Citation:
|
PMID: 22038876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Encephalitis associated with autoantibodies directed against the N-methyl-D-aspartate receptor (NMDAR) is usually a paraneoplastic syndrome that presents in young females with ovarian teratomas. We report a case of a previously healthy 14-year-old girl with sudden-onset paranoia, hallucinations, hyperactivity, increased speech, decreased sleep, seizures, and violent behavior deteriorating to catatonia. Her cerebrospinal fluid tested positive for anti-NMDAR antibodies. She was treated with five sessions of therapeutic plasma exchange (TPE) after having failed therapy with antibiotics, intravenous steroids, intravenous immunoglobulin (IVIG), one dose of rituximab, and seven sessions of electroconvulsive therapy (ECT). The American Society for Apheresis assigns a Category III (Grade 2C) recommendation for TPE in paraneoplastic neurologic syndromes; however, apheresis specifically for anti-NMDAR encephalitis has not been well studied. Literature review revealed two case reports describing outstanding improvement in patients with anti-NMDAR encephalitis following TPE. We report no improvement in our patient's symptoms after plasma exchange and discuss possible reasons for why it failed along with review of the literature. |
| | |
Authors:
|
M Kamran Mirza; Jennifer Pogoriler; Kristen Paral; Vijayalakshmi Ananthanarayanan; Saptarshi Mandal; Abdul Mazin; Beverly Baron; Elie Richa |
Related Documents
:
|
16864016 - Myelodysplastic syndrome presenting as acquired ichthyosis. 11297166 - The de barsy syndrome. 23400356 - Uterine perforation as a complication of surgical abortion causing small bowel obstruct... 21385006 - Urinary bladder paraganglioma in childhood: a case report and review of the literature. 9309756 - Amiodarone induced torsades de pointes with excessive qt dispersion following quinidine... 19568506 - Ectopic sebaceous glands in the esophagus: a case report and review of literature. |
Publication Detail:
|
Type: Case Reports; Journal Article; Review Date: 2011-10-29 |
Journal Detail:
|
Title: Journal of clinical apheresis Volume: 26 ISSN: 1098-1101 ISO Abbreviation: J Clin Apher Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-14 Completed Date: 2012-04-17 Revised Date: 2012-10-03 |
Medline Journal Info:
|
Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: United States |
Other Details:
|
Languages: eng Pagination: 362-5 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Pathology, Biological Sciences Division, Section of Blood Bank and Transfusion Medicine, The University of Chicago, Illinois, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Anti-N-Methyl-D-Aspartate Receptor Encephalitis / diagnosis, psychology, therapy* Catatonia / therapy Combined Modality Therapy Female Humans Plasma Exchange* Treatment Failure |
| Comments/Corrections | |
Comment In:
|
J Clin Apher. 2012;27(4):227-8
[PMID:
22411418
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Responses of chimpanzees to a recently dead community member at Gombe National Park, Tanzania.
Next Document: Simultaneous left maxillary and right mandibular reconstructions with a split osteomyocutaneous pero...