| Adjacent central venous catheters can result in immediate aspiration of infused drugs during renal replacement therapy. | |
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MedLine Citation:
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PMID: 22059378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dual-lumen haemodiafiltration catheters enable continuous renal replacement therapy in the critically ill and are often co-located with central venous catheters used to infuse drugs. The extent to which infusions are immediately aspirated by an adjacent haemodiafiltration catheter remains unknown. A bench model was constructed to evaluate this effect. A central venous catheter and a haemodiafiltration catheter were inserted into a simulated central vein and flow generated using centrifugal pumps within the simulated vein and haemodiafiltration circuit. Ink was used as a visual tracer and creatinine solution as a quantifiable tracer. Tracers were completely aspirated by the haemodiafiltration catheter unless the infusion was at least 1 cm downstream to the arterial port. No tracer was aspirated from catheters infusing at least 2 cm downstream. Orientation of side ports did not affect tracer elimination. Co-location of central venous and haemodiafiltration catheters may lead to complete aspiration of infusions into the haemodiafilter with resultant drug under-dosing. |
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Authors:
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K Y R Kam; J M Mari; T J Wigmore |
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Publication Detail:
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Type: Journal Article Date: 2011-11-08 |
Journal Detail:
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Title: Anaesthesia Volume: 67 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-18 Completed Date: 2012-02-28 Revised Date: 2012-10-31 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 115-21 Citation Subset: AIM; IM |
Copyright Information:
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Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland. |
Affiliation:
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Magill Department of Anaesthesia, Intensive Care and Pain Management, Imperial College London, Chelsea and Westminster Hospital, London, UK. ronald.kam02@imperial.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Catheterization, Central Venous / adverse effects* Catheters / adverse effects* Creatinine / analysis Hemodiafiltration Humans Infusion Pumps Infusions, Intravenous Models, Theoretical Renal Replacement Therapy* Respiratory Aspiration* Ultrasonography, Doppler, Duplex Vena Cava, Inferior / physiology Vena Cava, Superior / physiology |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
| Comments/Corrections | |
Comment In:
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Anaesthesia. 2012 Oct;67(10):1170
[PMID:
22950393
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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