Document Detail

Adjacent central venous catheters can result in immediate aspiration of infused drugs during renal replacement therapy.
MedLine Citation:
PMID:  22059378     Owner:  NLM     Status:  MEDLINE    
Dual-lumen haemodiafiltration catheters enable continuous renal replacement therapy in the critically ill and are often co-located with central venous catheters used to infuse drugs. The extent to which infusions are immediately aspirated by an adjacent haemodiafiltration catheter remains unknown. A bench model was constructed to evaluate this effect. A central venous catheter and a haemodiafiltration catheter were inserted into a simulated central vein and flow generated using centrifugal pumps within the simulated vein and haemodiafiltration circuit. Ink was used as a visual tracer and creatinine solution as a quantifiable tracer. Tracers were completely aspirated by the haemodiafiltration catheter unless the infusion was at least 1 cm downstream to the arterial port. No tracer was aspirated from catheters infusing at least 2 cm downstream. Orientation of side ports did not affect tracer elimination. Co-location of central venous and haemodiafiltration catheters may lead to complete aspiration of infusions into the haemodiafilter with resultant drug under-dosing.
K Y R Kam; J M Mari; T J Wigmore
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Publication Detail:
Type:  Journal Article     Date:  2011-11-08
Journal Detail:
Title:  Anaesthesia     Volume:  67     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-02-28     Revised Date:  2012-10-31    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-21     Citation Subset:  AIM; IM    
Copyright Information:
Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.
Magill Department of Anaesthesia, Intensive Care and Pain Management, Imperial College London, Chelsea and Westminster Hospital, London, UK.
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MeSH Terms
Catheterization, Central Venous / adverse effects*
Catheters / adverse effects*
Creatinine / analysis
Infusion Pumps
Infusions, Intravenous
Models, Theoretical
Renal Replacement Therapy*
Respiratory Aspiration*
Ultrasonography, Doppler, Duplex
Vena Cava, Inferior / physiology
Vena Cava, Superior / physiology
Reg. No./Substance:
Comment In:
Anaesthesia. 2012 Oct;67(10):1170   [PMID:  22950393 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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