Document Detail

Adiposity in adolescent offspring born prematurely to mothers with preeclampsia.
MedLine Citation:
PMID:  23211927     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the relationship between maternal preeclampsia resulting in premature delivery and adiposity in the offspring during adolescence.
STUDY DESIGN: The 172 study participants were 14 years old and had very low birth weight. We compared height, weight, body mass index (BMI), percent fat, waist circumference, and triceps and subscapular skin fold thicknesses between those born prematurely secondary to preeclampsia (n = 51; 22 male) and those born prematurely after normotensive pregnancies (n = 121; 55 male). Multiple linear regression analysis was used to adjust for potential confounders (maternal BMI, antenatal steroid exposure, and race) and to evaluate potential explanatory variables (fetal, infancy, and childhood weight gain, and caloric intake, level of fitness, and physical activity at 14 years).
RESULTS: When adjusted for potential prenatal confounders (antenatal steroid exposure and race), adolescent male offspring of preeclamptic pregnancies had higher BMI (4.0 kg/m(2) [1.5, 6.6]) (mean difference [95% CI]), waist circumference (11.8 cm [3.8, 19.7]), triceps (4.6 mm [0.6, 8.6]) and subscapular skinfold thicknesses (6.2 mm [1.5, 10.9]), and percent body fat (4.1% [-0.1, 8.3]). Adjusting for infancy and childhood weight gain attenuated these group differences. There were no group differences among females.
CONCLUSION: Male adolescent offspring born prematurely of women with preeclampsia have higher measures of adiposity than those born prematurely of normotensive pregnancies.
Lisa Washburn; Patricia Nixon; Gregory Russell; Beverly M Snively; T Michael O'Shea
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-01
Journal Detail:
Title:  The Journal of pediatrics     Volume:  162     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-07-12     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  912-7.e1     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Body Composition
Body Mass Index
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / etiology*
Infant, Very Low Birth Weight
Obesity / epidemiology,  etiology*
Pre-Eclampsia / epidemiology*
Prenatal Exposure Delayed Effects*
Risk Factors
Grant Support
Comment In:
J Pediatr. 2013 May;162(5):889-90   [PMID:  23415618 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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