| Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. | |
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MedLine Citation:
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PMID: 19833894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical implications. Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear. RESEARCH DESIGN AND METHODS: We investigated the relations of serum 25-hydroxyvitamin D (25[OH]D) concentrations with indexes of cardiometabolic risk in 3,890 nondiabetic individuals; 1,882 had subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volumes measured by multidetector computed tomography (CT). RESULTS: In multivariable-adjusted regression models, 25(OH)D was inversely associated with winter season, waist circumference, and serum insulin (P < 0.005 for all). In models further adjusted for CT measures, 25(OH)D was inversely related to SAT (-1.1 ng/ml per SD increment in SAT, P = 0.016) and VAT (-2.3 ng/ml per SD, P < 0.0001). The association of 25(OH)D with insulin resistance measures became nonsignificant after adjustment for VAT. Higher adiposity volumes were correlated with lower 25(OH)D across different categories of BMI, including in lean individuals (BMI <25 kg/m(2)). The prevalence of vitamin D deficiency (25[OH]D <20 ng/ml) was threefold higher in those with high SAT and high VAT than in those with low SAT and low VAT (P < 0.0001). CONCLUSIONS: Vitamin D status is strongly associated with variation in subcutaneous and especially visceral adiposity. The mechanisms by which adiposity promotes vitamin D deficiency warrant further study. |
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Authors:
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Susan Cheng; Joseph M Massaro; Caroline S Fox; Martin G Larson; Michelle J Keyes; Elizabeth L McCabe; Sander J Robins; Christopher J O'Donnell; Udo Hoffmann; Paul F Jacques; Sarah L Booth; Ramachandran S Vasan; Myles Wolf; Thomas J Wang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-15 |
Journal Detail:
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Title: Diabetes Volume: 59 ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-30 Completed Date: 2010-02-25 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 242-8 Citation Subset: AIM; IM |
Affiliation:
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Framingham Heart Study, Framingham, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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anatomy & histology* Adipose Tissue / anatomy & histology* Adult Blood Pressure Cardiovascular Diseases / epidemiology* Cholesterol, HDL / blood Cohort Studies European Continental Ancestry Group Female Glucose Intolerance / epidemiology Humans Hypertension / epidemiology Longitudinal Studies Male Middle Aged Obesity / epidemiology* Tomography, X-Ray Computed Triglycerides / blood Vitamin D / analogs & derivatives*, blood, metabolism* Vitamin D Deficiency / complications* |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-25195/HC/NHLBI NIH HHS; R01-DK-80739/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Triglycerides; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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