| Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma. | |
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MedLine Citation:
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PMID: 21222563 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Epidemiological studies have shown that obesity/adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity/adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity/adiposity in nonasthmatic healthy adults. Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity/adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses. Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-α, or interleukin (IL)-6 was observed. Conclusions. These findings suggest that in healthy subjects without asthma, obesity/adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation. |
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Authors:
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Sang-Heon Kim; Tae Hyung Kim; Ji Seon Lee; Tai Yeon Koo; Chang Beom Lee; Ho Joo Yoon; Dong Ho Shin; Sung Soo Park; Jang Won Sohn |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-12 |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: - ISSN: 1532-4303 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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