Document Detail

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids.
MedLine Citation:
PMID:  19965578     Owner:  NLM     Status:  MEDLINE    
FAs are mobilized from triglyceride (TG) stores during exercise to supply the working muscle with energy. Mice deficient for adipose triglyceride lipase (ATGL-ko) exhibit defective lipolysis and accumulate TG in adipose tissue and muscle, suggesting that ATGL deficiency affects energy availability and substrate utilization in working muscle. In this study, we investigated the effect of moderate treadmill exercise on blood energy metabolites and liver glycogen stores in mice lacking ATGL. Because ATGL-ko mice exhibit massive accumulation of TG in the heart and cardiomyopathy, we also investigated a mouse model lacking ATGL in all tissues except cardiac muscle (ATGL-ko/CM). In contrast to ATGL-ko mice, these mice did not accumulate TG in the heart and had normal life expectancy. Exercise experiments revealed that ATGL-ko and ATGL-ko/CM mice are unable to increase circulating FA levels during exercise. The reduced availability of FA for energy conversion led to rapid depletion of liver glycogen stores and hypoglycemia. Together, our studies suggest that ATGL-ko mice cannot adjust circulating FA levels to the increased energy requirements of the working muscle, resulting in an increased use of carbohydrates for energy conversion. Thus, ATGL activity is required for proper energy supply of the skeletal muscle during exercise.
Gabriele Schoiswohl; Martina Schweiger; Renate Schreiber; Gregor Gorkiewicz; Karina Preiss-Landl; Ulrike Taschler; Kathrin A Zierler; Franz P W Radner; Thomas O Eichmann; Petra C Kienesberger; Sandra Eder; Achim Lass; Guenter Haemmerle; Thomas J Alsted; Bente Kiens; Gerald Hoefler; Rudolf Zechner; Robert Zimmermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-25
Journal Detail:
Title:  Journal of lipid research     Volume:  51     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-05-07     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-9     Citation Subset:  IM    
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MeSH Terms
Carbohydrates / blood
Carboxylic Ester Hydrolases / deficiency,  genetics,  metabolism*
Energy Metabolism
Fatty Acids / metabolism*
Gene Knockout Techniques
Glycogen / metabolism
Lipids / blood
Liver / metabolism
Muscles / cytology,  metabolism*,  physiology
Physical Conditioning, Animal
Grant Support
F 3001-B19//Austrian Science Fund FWF; F 3002-B19//Austrian Science Fund FWF; P 18434-B05//Austrian Science Fund FWF; W 901-B12//Austrian Science Fund FWF
Reg. No./Substance:
0/Carbohydrates; 0/Fatty Acids; 0/Lipids; 9005-79-2/Glycogen; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC protein, mouse; EC
Comment In:
J Lipid Res. 2010 Mar;51(3):449-50   [PMID:  20007838 ]

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