Document Detail


Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat.
MedLine Citation:
PMID:  11739084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated angiotensinogen (AGT) expression in adipose tissue and liver of Zucker rats during the onset of obesity. The developmental pattern of AGT expression (protein and mRNA) in liver was similar in both genotypes. In inguinal adipose tissue, AGT cell content was similar in suckling and weaned pups in lean rats, whereas it continuously increased with age in obese rats. AGT amount in adipocytes was unaffected by the genotype until weaning. Thereafter, adipocytes from obese rats displayed a significant increase in AGT content that was strengthened with age. Compared with the cell content, the amount of secreted AGT over 24 h was higher, and a genotype effect was observed as early as 14 days of age. Using fat cell populations differing by size, we showed that this AGT oversecretion was not solely related to adipocyte hypertrophy. Our results demonstrate that the fa genotype exerts a control on the production of AGT in a tissue-specific manner, suggesting a local role of AGT in the overdevelopment of adipose tissue.
Authors:
Isabelle Hainault; Guillaume Nebout; Sophie Turban; Bernadette Ardouin; Pascal Ferré; Annie Quignard-Boulangé
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  282     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E59-66     Citation Subset:  IM    
Affiliation:
Institut National de la Santé et de la Recherche Médicale U 465, Centre Biomédical des Cordeliers, Université Pierre et Marie Curie, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism
Adipose Tissue / cytology,  metabolism*
Angiotensinogen / genetics,  metabolism*
Animals
Cell Size
Cells, Cultured
Genotype
Liver / metabolism
Obesity / genetics,  metabolism*
RNA, Messenger / metabolism
Rats
Rats, Zucker / metabolism*
Reference Values
Chemical
Reg. No./Substance:
0/RNA, Messenger; 11002-13-4/Angiotensinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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