Document Detail


Adipose tissue metabolism in benign symmetric lipomatosis.
MedLine Citation:
PMID:  11397876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Type 2 benign symmetric lipomatosis (BSL) is characterized by abnormal growth of adipose tissue in the upper back, deltoid region, upper arms, hips, and upper thigh region. Studies of lipomatous tissue in vitro have suggested that defective lipolysis may account for excess fat accumulation; however, in vivo adipose tissue metabolism has not been evaluated. We measured systemic adipose tissue lipolysis and regional adipose tissue fatty acid uptake in a patient with type 2 BSL scheduled for elective brachioplasty. We found increased, rather than decreased, rates of systemic free fatty acid release coupled with normal fatty acid oxidation. The uptake of fatty acids was 19% greater in deltoid region lipomatous tissue than in abdominal sc fat, whereas in control studies the relative uptake of fatty acids in deltoid fat averaged 29% less than that in abdominal fat. Adipocyte size was smaller than expected in lipomatous tissue. These results suggest that type 2 BSL is a hyperplastic adipose tissue abnormality that does not impair systemic lipolysis. The pathophysiology appears similar to what has been termed hyperplastic obesity. A better understanding of this condition could lead to insights into the mechanisms of hyperplastic obesity.
Authors:
S Nielsen; J Levine; R Clay; M D Jensen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  86     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-08     Completed Date:  2001-07-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2717-20     Citation Subset:  AIM; IM    
Affiliation:
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Body Composition
Energy Metabolism
Epinephrine / blood
Fatty Acids / metabolism
Female
Humans
Insulin / blood
Kinetics
Lipomatosis, Multiple Symmetrical / metabolism*,  pathology
Middle Aged
Norepinephrine / blood
Osmolar Concentration
Grant Support
ID/Acronym/Agency:
DK-45343/DK/NIDDK NIH HHS; DK-50456/DK/NIDDK NIH HHS; RR-0585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 11061-68-0/Insulin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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