Document Detail

Adipose tissue infiltration in skeletal muscle: age patterns and association with diabetes among men of African ancestry.
MedLine Citation:
PMID:  18541544     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although obesity is strongly associated with diabetes, the greater prevalence of diabetes in persons of African ancestry than in those of other ancestries cannot be explained simply by differences in total or central adiposity.
OBJECTIVE: We examined whether skeletal muscle composition is associated with diabetes in 1249 men of African ancestry aged >or=40 y.
DESIGN: Anthropometry and fasting serum glucose were measured, and lower-leg skeletal muscle composition was assessed with peripheral quantitative computerized tomography (pQCT).
RESULTS: The prevalence of diabetes in this population was high (21%). We observed an age-associated adipose tissue remodeling in skeletal muscle and greater intermuscular (IMAT) and lesser subcutaneous (SAT) adipose tissue area with advancing age (P < 0.0001). Multivariate stepwise logistic regression identified more IMAT and less SAT to be significantly associated with a greater prevalence of diabetes. Even among normal-weight men [body mass index (BMI; in kg/m(2)) < 25], diabetic men had significantly (P = 0.01) more IMAT than did those without diabetes. Greater IMAT was also associated with a greater prevalence of hyperglycemia in men with a family history of diabetes than in those without such history (P for interaction = 0.02).
CONCLUSIONS: These findings underscore the independent associations of subcutaneous and intermuscular fat among men of African ancestry, an effect that may be modified by a family history of diabetes. Further studies are needed to identify the genetic and physiologic mechanisms that influence the distribution and remodeling of adipose tissue in skeletal muscle with aging.'
Iva Miljkovic-Gacic; Christopher L Gordon; Bret H Goodpaster; Clareann H Bunker; Alan L Patrick; Lewis H Kuller; Victor W Wheeler; Rhobert W Evans; Joseph M Zmuda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-01     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1590-5     Citation Subset:  AIM; IM    
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MeSH Terms
Adipose Tissue / growth & development*,  physiology*
African Continental Ancestry Group* / statistics & numerical data
Aging / physiology*
Blood Glucose / analysis
Body Mass Index
Diabetes Mellitus / epidemiology*
Middle Aged
Muscle, Skeletal / growth & development*,  physiology*
Regression Analysis
Trinidad and Tobago
Grant Support
F32 HL083641/HL/NHLBI NIH HHS; F32 HL083641/HL/NHLBI NIH HHS; F32 HL083641-01/HL/NHLBI NIH HHS; F32 HL083641-02/HL/NHLBI NIH HHS; R01 AR049747/AR/NIAMS NIH HHS; R01 AR049747-01A1/AR/NIAMS NIH HHS; R01 AR049747-02/AR/NIAMS NIH HHS; R01 AR049747-03/AR/NIAMS NIH HHS; R01 AR049747-04/AR/NIAMS NIH HHS; R01 AR049747-05/AR/NIAMS NIH HHS; R01AR049747/AR/NIAMS NIH HHS
Reg. No./Substance:
0/Blood Glucose
Comment In:
Am J Clin Nutr. 2008 Jun;87(6):1585-6   [PMID:  18541542 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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