Document Detail


Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties.
MedLine Citation:
PMID:  2591189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The occurrence and relative abundance of adipose tissue around the heart and in the pericardium of wild and domesticated mammals are reviewed and some new data reported. 2. For macaque monkeys and a wide range of other adult mammals, the mean volume of epicardial adipocytes is constant at about half the average of that of other depots, although the relative mass of this depot is unrelated to the abundance of adipose tissue in the rest of the body. 3. In young adult guinea-pigs, the maximum rate of fatty acid synthesis is significantly higher in epicardial adipose tissue than that in the pericardial, perirenal and popliteal depots. 4. The rate of fatty acid release by epicardial adipose tissue is approximately twice that of the pericardial and perirenal depots. 5. The protein contents of guinea-pig epicardial and pericardial adipose tissue are similar, and are significantly higher than those of the perirenal and popliteal adipose tissue and there are no site-specific differences in the abundance of mitochondria. 6. In adult Macaca monkeys, the capacity of the epicardial adipose tissue for glucose utilization is about half that of the intra-abdominal depots. 7. The principal difference between epicardial adipose tissue and that elsewhere in the body is its greater capacity for fatty acid release. 8. It is suggested that cardiac adipose tissue may act as a local energy supply for adjacent myocardium and/or as a buffer against toxic levels of free fatty acids.
Authors:
J M Marchington; C A Mattacks; C M Pond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  94     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Affiliation:
Department of Biology, Open University, Milton Keynes, UK.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / analysis,  anatomy & histology*,  metabolism
Animals
Animals, Domestic / anatomy & histology
Animals, Laboratory / anatomy & histology
Animals, Wild / anatomy & histology
Body Weight
Fatty Acids / metabolism
Heart / anatomy & histology*,  embryology
Histocytochemistry
Mammals / anatomy & histology*
Myocardium / analysis
Pericardium / analysis,  anatomy & histology*,  embryology
Proteins / analysis
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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