Document Detail

Adipose tissue fatty acids in men from two populations with different cardiovascular risk: the LiVicordia study.
MedLine Citation:
PMID:  10400167     Owner:  NLM     Status:  MEDLINE    
The LiVicordia study was set up to investigate possible causes for coronary heart disease mortality in middle-aged Lithuanian men being four times higher than in Swedish men. In a previous part of this study we found lower total and low density lipoprotein (LDL) cholesterol in the Lithuanian men in spite of them having a higher fat intake than in the Swedish men. Their LDL was also more susceptible to oxidation in vitro than was that of the Swedish men. Fat quality can influence LDL oxidation. In order to obtain data on long-term fat quality intake we measured the fatty acid composition of abdominal wall adipose tissue by gas chromatography in men aged 50 years from Vilnius, Lithuania (n=50) and Linköping, Sweden (n=50). Men from Vilnius had a significantly higher percentage of adipose tissue long chain polyunsaturated fatty acids (PUFA) (20:4n6, 20:5n3, 22:5n5, 22:6n3) and lower percentage of saturated fatty acids, especially myristic acid (14:0), 3.4+/-0.7 versus 4.6+/-0.8, p<0.0001. The percentage content of adipose tissue linoleic acid (18:2n6) was 11.5+/-2.1 versus 11.0+/-1.4 (n.s.) and of linolenic acid (18:3n3) 0.7+/-0.3 versus 0.6+/-0.2 (n.s.) in men from Vilnius and Linköping, respectively. It is concluded that the adipose tissue content of essential fatty acids is similar in men from Vilnius and men from Linköping and therefore the intake is also likely to be similar. The higher contents of long chain highly unsaturated fatty acids in men from Vilnius may be of importance in the oxidation process of LDL.
A Kaminskas; B Ziedén; B Elving; M Kristenson; A Abaravicius; B Bergdahl; A G Olsson; Z Kucinskiene
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  59     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-09-03     Completed Date:  1999-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Department of Physiology and Biochemistry, Faculty of Medicine, Vilnius, Lithuania.
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MeSH Terms
Adipose Tissue / chemistry*
Body Mass Index
Coronary Disease / epidemiology*,  metabolism*
Diet, Atherogenic
Dietary Fats / analysis
Fatty Acids / analysis*
Fatty Acids, Unsaturated / analysis*
Lipid Peroxidation / physiology
Lipoproteins, LDL / metabolism
Lithuania / epidemiology
Middle Aged
Myristic Acid / analysis
Risk Factors
Sweden / epidemiology
alpha-Linolenic Acid / analysis
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 463-40-1/alpha-Linolenic Acid; 544-63-8/Myristic Acid

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