Document Detail

Adipose-tissue fatty acid composition in recipients of long-term total parenteral nutrition (TPN).
MedLine Citation:
PMID:  1903586     Owner:  NLM     Status:  MEDLINE    
Adipose-tissue fatty acid composition was studied in nine patients requiring long-term total parenteral nutrition (TPN). The patients received 17 +/- 8% of total energy as soybean-oil emulsion (Intralipid) and 66 +/- 8% as glucose. Despite low intake of 9c-16:1, 11c-18:1, and 13c-18:1, adipose-tissue concentrations of these monounsaturated fatty acids were higher in the TPN patients than in free-living control subjects (P less than 0.05) and inversely correlated with the percent energy from fat (r = -0.56, P = 0.11; r = -0.64, P = 0.06; r = -0.81, P = 0.008, respectively). This suggests that these fatty acids accumulated from endogenous synthesis from carbohydrate and thus may be markers of the percent fat in the diet. The essential fatty acids, 18:2 and 18:3n-3, positively correlated with the percent energy from fat (r = 0.79, P = 0.01; r = 0.80, P = 0.01, respectively). Linear-regression analysis suggests that normal adipose-tissue stores of 18:2 and 18:3n-3 are maintained when intravenous soybean-oil emulsion provides 11-20% and 4-12%, respectively, of total energy.
Y Ito; L C Hudgins; J Hirsch; M Shike
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  53     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-21     Completed Date:  1991-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1487-92     Citation Subset:  AIM; IM    
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
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MeSH Terms
Adipose Tissue / chemistry*
Dietary Fats / administration & dosage
Fat Emulsions, Intravenous / administration & dosage
Fatty Acids / analysis*
Glucose / administration & dosage
Middle Aged
Parenteral Nutrition, Total*
Regression Analysis
Soybean Oil / administration & dosage
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids; 50-99-7/Glucose; 8001-22-7/Soybean Oil

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