| Adipose-tissue fatty acid composition in recipients of long-term total parenteral nutrition (TPN). | |
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MedLine Citation:
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PMID: 1903586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adipose-tissue fatty acid composition was studied in nine patients requiring long-term total parenteral nutrition (TPN). The patients received 17 +/- 8% of total energy as soybean-oil emulsion (Intralipid) and 66 +/- 8% as glucose. Despite low intake of 9c-16:1, 11c-18:1, and 13c-18:1, adipose-tissue concentrations of these monounsaturated fatty acids were higher in the TPN patients than in free-living control subjects (P less than 0.05) and inversely correlated with the percent energy from fat (r = -0.56, P = 0.11; r = -0.64, P = 0.06; r = -0.81, P = 0.008, respectively). This suggests that these fatty acids accumulated from endogenous synthesis from carbohydrate and thus may be markers of the percent fat in the diet. The essential fatty acids, 18:2 and 18:3n-3, positively correlated with the percent energy from fat (r = 0.79, P = 0.01; r = 0.80, P = 0.01, respectively). Linear-regression analysis suggests that normal adipose-tissue stores of 18:2 and 18:3n-3 are maintained when intravenous soybean-oil emulsion provides 11-20% and 4-12%, respectively, of total energy. |
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Authors:
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Y Ito; L C Hudgins; J Hirsch; M Shike |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 53 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-06-21 Completed Date: 1991-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1487-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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chemistry* Adult Aged Dietary Fats / administration & dosage Fat Emulsions, Intravenous / administration & dosage Fatty Acids / analysis* Female Glucose / administration & dosage Humans Male Middle Aged Parenteral Nutrition, Total* Regression Analysis Soybean Oil / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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HL01565/HL/NHLBI NIH HHS; M01-RR00102/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids; 50-99-7/Glucose; 8001-22-7/Soybean Oil |
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