Document Detail


Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency.
MedLine Citation:
PMID:  11352185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Lipid stores in human adipose tissue are maintained primarily by incorporating lipid from circulating chylomicrons and very low density lipoproteins. Adipose tissue lipoprotein lipase (LPL) hydrolyzes triglyceride from these lipoprotein particles to facilitate their entry into adipocytes for storage. Subjects deficient in LPL still have normal adiposity, and this may result from increased adipocyte lipogenesis or from uptake of circulating lipid through alternate mechanisms. The objective of this study was to determine whether fatty acid composition of adipose tissue from LPL-deficient subjects reflects maintenance of lipid stores through increased lipogenesis or through alternate mechanisms of lipoprotein uptake. METHODS: Adipose tissue samples from LPL-deficient subjects who consume fat-restricted diets and normal subjects were analyzed for fatty acid composition by gas-liquid chromatography. RESULTS: Compared with that of normal subjects, adipose tissue from LPL-deficient subjects showed an increase in 16:1 and decreases in 18:0, 18:2, and 18:3 fatty acids, whereas other nonessential fatty acid levels were not statistically different. CONCLUSIONS: The reduction in essential fatty acids and increase in nonessential fatty acids in adipose tissue of those with LPL deficiency, taken together with recent data from animal studies, suggest that lipid stores in these subjects are maintained primarily through enhanced adipocyte lipogenesis.
Authors:
N F Ullrich; J Q Purnell; J D Brunzell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  49     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Washington School of Medicine, Seattle 30086, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*
Adult
Child
Fatty Acids / analysis*
Female
Heterozygote
Homozygote
Humans
Hyperlipoproteinemia Type I / genetics,  metabolism*
Lipoprotein Lipase / genetics
Male
Mutation, Missense
Grant Support
ID/Acronym/Agency:
HL 30086/HL/NHLBI NIH HHS; K23 DK02689/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; EC 3.1.1.34/Lipoprotein Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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