Document Detail


Adipose tissue dynamics during cyclic weight loss and weight gain of ground squirrels.
MedLine Citation:
PMID:  2735455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ad libitum fed golden-mantled ground squirrels undergo marked annual fluctuations in body mass; during the first cycle, peak and trough masses were approximately 291 and approximately 192 g, respectively. Peak masses were significantly higher (9%) during the second than the first cycle, reflecting a 15% increase in fat-free dry mass and a 12% increase in lipid reserves. The reduction in body mass during the weight loss phase was almost entirely due to an 84% decrease in total lipid reserves and reflected a decrease in adipocyte size but not number. All measured fat depots decreased at similar rates, and there was no evidence of preferential utilization or sparing of individual depots. Fat cell size decreased progressively in each depot during the transition from peak to trough masses and did not vary among the several depots at any stage of annual cycle. Adipocyte number increased in parametrial and retroperitoneal depots but not in the subcutaneous fat between the first and second body mass peaks; fat cell size in these two depots decreased by 28 and 20%, respectively, from the first to the second peak in body mass. Reduced lipid filling of adipocytes at the second peak mass, concomitant with adipocyte hyperplasia, suggests that total lipid mass, not simply fat cell size, is regulated during the annual body mass cycle. Maturation of the subcutaneous fat depot before the initial entry into hibernation may be adaptive in providing insulation during dormancy.
Authors:
J Dark; J S Stern; I Zucker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-18     Completed Date:  1989-07-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1286-92     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / cytology,  physiology*
Animals
Female
Periodicity*
Sciuridae / physiology*
Weight Gain*
Weight Loss*
Grant Support
ID/Acronym/Agency:
DK-18899/DK/NIDDK NIH HHS; HD-14595/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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