Document Detail


Adipose tissue detected by multislice computed tomography in patients after myocardial infarction.
MedLine Citation:
PMID:  19442939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Our aim was to investigate the frequency of left ventricular (LV) and right ventricular adipose tissue on multislice computed tomography (CT) in patients with a history of myocardial infarction (MI) and to determine correlations with infarct age. BACKGROUND: Fat deposition in the ventricular wall has frequently been observed in post-infarct myocardial tissue. However, the in vivo relevance of adipose tissue in MI on CT and correlations with infarct age have not been determined. METHODS: Fifty-three patients with a history of MI (mean age 66 +/- 10 years; 38 men, 15 women) and 63 subjects with no history of MI or coronary revascularization (mean age 65 +/- 12 years; 37 men, 26 women) were retrospectively studied for intramyocardial fat on 64-slice cardiac CT. Presence or absence, distribution, and correlations with infarct age of LV adipose tissue were evaluated. RESULTS: Compared with noninfarct control subjects, the MI group showed a significantly higher prevalence of fat deposition within LV myocardium on CT (MI group, 62% [33 of 53] vs. control group, 3% [2 of 63]; p < 0.0001). In 32 of 33 patients (97%) with MI and LV fat deposition on CT, adipose tissue was observed in the region perfused by the infarct-related artery and was located in the subendocardium in 30 patients (94%), the middle layer in 1 patient (3%), and the subepicardium in 1 patient (3%). Mean infarct age was significantly higher in patients with LV adipose tissue (8.2 +/- 4.4 years) than in those without adipose tissue (2.2 +/- 2.6 years, p < 0.001). Thirty of 35 patients (89%) with infarct age >or=3 years showed adipose tissue in MI. Conversely, none of 9 patients with infarct age <10 months showed fatty replacement. CONCLUSIONS: Myocardial adipose tissue is common in patients with infarct age >or=3 years. CT evaluation of myocardial adipose tissue may be important for accurate interpretation of CT perfusion and infarct imaging of the heart.
Authors:
Yasutaka Ichikawa; Kakuya Kitagawa; Shuji Chino; Masaki Ishida; Koji Matsuoka; Takashi Tanigawa; Tomoaki Nakamura; Tadanori Hirano; Kan Takeda; Hajime Sakuma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JACC. Cardiovascular imaging     Volume:  2     ISSN:  1876-7591     ISO Abbreviation:  JACC Cardiovasc Imaging     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-15     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101467978     Medline TA:  JACC Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  548-55     Citation Subset:  IM    
Affiliation:
Department of Radiology, Matsusaka Central Hospital, Mie, Japan. yasutaka@clin.medic.mie-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / radiography*
Aged
Female
Heart Ventricles / radiography
Humans
Lipomatosis / radiography*
Male
Metaplasia
Middle Aged
Myocardial Infarction / radiography*
Myocardium / pathology*
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Retrospective Studies
Time Factors
Tomography, Spiral Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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