Document Detail


Adipose tissue biology and cardiomyopathy: translational implications.
MedLine Citation:
PMID:  23223931     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is epidemiologically established that obesity is frequently associated with the metabolic syndrome and poses an increased risk for the development of type 2 diabetes mellitus and cardiovascular disease. The molecular links that connect the phenomenon of obesity, per se, with insulin resistance and cardiovascular disease are still not fully elucidated. It is increasingly apparent that fully functional adipose tissue can be cardioprotective by reducing lipotoxic effects in other peripheral tissues and by maintaining a healthy balance of critical adipokines, thereby allowing the heart to maintain its full metabolic flexibility. The present review highlights both basic and clinical findings that emphasize the complex interplay of adipose tissue physiology and adipokine-mediated effects on the heart exerted by either direct effects on cardiac myocytes or indirect actions via central mechanisms through sympathetic outflow to the heart.
Authors:
Aslan T Turer; Joseph A Hill; Joel K Elmquist; Philipp E Scherer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Circulation research     Volume:  111     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-02-06     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1565-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipokines / genetics,  metabolism
Adipose Tissue / metabolism*,  pathology
Animals
Cardiomyopathies / genetics*,  metabolism*
Humans
Insulin Resistance / genetics
Obesity / genetics,  metabolism
Translational Medical Research* / methods,  trends
Grant Support
ID/Acronym/Agency:
HL-075173/HL/NHLBI NIH HHS; HL-080144/HL/NHLBI NIH HHS; HL-090842/HL/NHLBI NIH HHS; P01 DK088761/DK/NIDDK NIH HHS; P01-DK088761/DK/NIDDK NIH HHS; P01DK088761/DK/NIDDK NIH HHS; R01 DK055758/DK/NIDDK NIH HHS; R01-DK53301/DK/NIDDK NIH HHS; R01-DK55758/DK/NIDDK NIH HHS; RL-1DK081185/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Adipokines
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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