| Adipose Tissue Dysfunction in Polycystic Ovary Syndrome. | |
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MedLine Citation:
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PMID: 21424395 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among premenopausal women. In addition to infertility, PCOS is associated with insulin resistance, features of the metabolic syndrome, and an increased risk for diabetes. Similar to individuals with metabolic syndrome, many women with PCOS manifest abdominal obesity, suggesting adipose tissue dysfunction. The adipose tissue of women with PCOS is characterized by hypertrophic adipocytes and impairments in lipolysis and insulin action. The expression and secretion of a wide variety of adipokines implicated in insulin resistance, including adiponectin and others, are also altered in PCOS. Collectively, the available data indicate that adipose tissue dysfunction plays a central role in the metabolic abnormalities observed in PCOS. Whether these abnormalities are primary or secondary to hyperandrogenism or other abnormalities in PCOS is not yet known. |
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Authors:
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Jennifer Villa; Richard E Pratley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-19 |
Journal Detail:
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Title: Current diabetes reports Volume: - ISSN: 1539-0829 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Diabetes and Metabolism Translational Medicine Unit, University of Vermont College of Medicine, Colchester Research Facility, 110C, 208 South Park Street, Colchester, 05446, VT, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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