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Adipoparacrinology: vascular periadventitial adipose tissue (tunica adiposa) as an example.
MedLine Citation:
PMID:  22150107     Owner:  NLM     Status:  Publisher    
In humans, adipose tissue is partitioned into 2 large depots (subcutaneous and visceral), and many small depots associated with internal organs, e.g. heart, blood vessels, major lymph nodes, pancreas, prostate gland, ovaries. Since the adipose's Big Bang was explored with the discovery of leptin in 1994, adipose tissue has been recognized as not merely lipid storage, but a secretory - endocrine and paracrine - organ, particularly in the pathogenesis of various diseases. Accordingly, 2 major sub-fields of adipobiology have emerged, adipoendocrinology and adipoparacrinology, the latter is herein illustrated with the periadventitial adipose tissue (PAAT) in vascular walls. A long-standing paradigm holds that a vascular wall consists of 3 coats: tunica intima, t. media, and t. adventitia. Today, it is imperative that "to further elucidate vascular function, we should no longer, as hitherto, cut adventitia and PAAT from the vascular wall, but keep them attached and in place, and subject to thorough examination" (Chaldakov et al., 2000, 2001). From these data we propose that it is time to rethink vascular wall composition, suggesting that the PAAT may be considered the fourth and outermost vascular coat, hence, tunica adiposa (regarding the proximal segment of coronary artery, it is the innermost part of the epicardial adipose tissue situated around the coronary adventitia). Its significance in the pathogenesis and therapy of cardiometabolic diseases, particularly atherosclerosis and hypertension, requires further basic, translational and clinical studies.
George Nikov Chaldakov; Jerzy Beltowsky; Peter I Ghenev; Marco Fiore; Plamen Panayatov; Gorana Rancic; Luigi Aloe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-12
Journal Detail:
Title:  Cell biology international     Volume:  -     ISSN:  1095-8355     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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