| Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men. | |
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MedLine Citation:
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PMID: 23040831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several risk factors as possible independent predictors of aortic stiffness progression among a population-based sample of US men. METHODS: A total of 240 men (40-49 years) free of CVD at baseline from the Pittsburgh site of the ERA JUMP study were evaluated. Aortic stiffness was measured as carotid-femoral pulse wave velocity at baseline and after 4.6 ± 0.2 (mean ± SD) years of follow-up. Progression of aortic stiffness was evaluated as relative annual change in carotid-femoral pulse wave velocity (% change/year). Using linear regression, both baseline potential risk factors and their annual changes were evaluated as possible risk factors for aortic stiffness progression. Baseline age, follow-up time, race, heart rate, and medications use were forced in all models. RESULTS: During follow-up, relative to baseline level, aortic stiffness increased 0.3% ± 5.3% per year. In final models, the independent predictors of degree of aortic stiffness progression were lower levels of adiponectin (P = 0.03), higher levels of systolic blood pressure (P = 0.03), greater annual change in systolic blood pressure (P = 0.04), and alcohol consumption ≥ 2 times/week (P = 0.02). Adiponectin levels within the third (9.8 μg/Ml ≤ adiponectin < 13.0 μg/mL) and the fourth (adiponectin ≥ 13.0 μg/mL) quartiles were associated with an improvement in relative annual aortic stiffness progression (P = 0.02, P = 0.01, respectively) compared to levels within the first quartile (adiponectin ≤ 7.0 μg/mL). CONCLUSION: Among apparently healthy men, lower levels of baseline adiponectin could be a novel marker for greater risk of aortic stiffness progression. Longitudinal research is required to evaluate whether adiponectin change over time would have similar association with aortic stiffness progression. |
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Authors:
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Samar R El Khoudary; Emma Barinas-Mitchell; Jessica White; Kim Sutton-Tyrrell; Lewis H Kuller; J David Curb; Chol Shin; Hirotsugu Ueshima; Kamal Masaki; Rhobert W Evans; Katsuyuki Miura; Daniel Edmundowicz; Akira Sekikawa; |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-09-23 |
Journal Detail:
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Title: Atherosclerosis Volume: 225 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-20 Completed Date: 2013-05-02 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 475-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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University of Pittsburgh, Pittsburgh, PA 15261, USA. elkhoudarys@edc.pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adult Alcohol Drinking / blood*, epidemiology, physiopathology* Aorta / physiopathology* Atherosclerosis / blood*, diagnosis, epidemiology, physiopathology* Biological Markers / blood Blood Pressure* Disease Progression Down-Regulation Humans Linear Models Male Middle Aged Multivariate Analysis Pennsylvania / epidemiology Pulse Wave Analysis Risk Factors Systole Time Factors Vascular Stiffness* |
| Grant Support | |
ID/Acronym/Agency:
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HL071561/HL/NHLBI NIH HHS; R01 HL068200/HL/NHLBI NIH HHS; R01 HL071561/HL/NHLBI NIH HHS; R01 HL68200/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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