Document Detail

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway.
MedLine Citation:
PMID:  19254698     Owner:  NLM     Status:  MEDLINE    
Adiponectin, one of the insulin-sensitizing adipokines, has been shown to activate fatty acid oxidation in liver and skeletal muscle, thus maintaining insulin sensitivity. However, the precise roles of adiponectin in fatty acid synthesis are poorly understood. Here we show that adiponectin administration acutely suppresses expression of sterol regulatory element-binding protein (SREBP) 1c, the master regulator which controls and upregulates the enzymes involved in fatty acid synthesis, in the liver of +Lepr(db)/+Lepr(db) (db/db) mouse as well as in cultured hepatocytes. We also show that adiponectin suppresses SREBP1c by AdipoR1, one of the functional receptors for adiponetin, and furthermore that suppressing either AMP-activated protein kinase (AMPK) via its upstream kinase LKB1 deletion cancels the negative effect of adiponectin on SREBP1c expression. These data show that adiponectin suppresses SREBP1c through the AdipoR1/LKB1/AMPK pathway, and suggest a possible role for adiponectin in the regulation of hepatic fatty acid synthesis.
Motoharu Awazawa; Kohjiro Ueki; Kazunori Inabe; Toshimasa Yamauchi; Kazuma Kaneko; Yukiko Okazaki; Nabeel Bardeesy; Shin Ohnishi; Ryozo Nagai; Takashi Kadowaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-28
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  382     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-05-12     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
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MeSH Terms
Adiponectin / genetics,  pharmacology,  physiology
Fatty Acids / metabolism*
Hepatocytes / drug effects,  metabolism
Liver / drug effects,  metabolism*
Mice, Mutant Strains
Protein Kinases / metabolism
Protein-Serine-Threonine Kinases / metabolism
Receptors, Adiponectin / metabolism
Recombinant Proteins / pharmacology
Sterol Regulatory Element Binding Protein 1 / biosynthesis*
Reg. No./Substance:
0/Adiponectin; 0/Adipoq protein, mouse; 0/Fatty Acids; 0/Receptors, Adiponectin; 0/Recombinant Proteins; 0/Srebf1 protein, mouse; 0/Sterol Regulatory Element Binding Protein 1; 0/adiponectin receptor 1, mouse; EC 2.7.-/Protein Kinases; EC 2.7.1.-/AMP-activated protein kinase kinase; EC 2.7.1.-/Stk11 protein, mouse; EC Kinases

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