Document Detail

Adiponectin is released from the heart in patients with heart failure.
MedLine Citation:
PMID:  18192035     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Plasma levels of adiponectin are decreased in patients with ischemic heart disease, but increased in patients with heart failure (HF). The source of increased adiponectin levels in patients with HF remains unknown. This study examined whether adiponectin, an adipocyte-derived protein with cardioprotective actions, is released from the heart in patients with HF. METHODS: Plasma adiponectin levels sampled from the aorta, coronary sinus (CS), and peripheral vein (PV) were measure by ELISA in 138 consecutive patients with left ventricular ejection fraction (LVEF) <40% and in 40 normal controls. RESULTS: PV adiponectin levels were significantly higher in patients with either non-ischemic HF (n=81) or ischemic HF (n=57) than controls; levels were similar between patients with non-ischemic HF and those with ischemic HF. There was a significant step-up in adiponectin levels from the aorta to the CS in patients with either non-ischemic HF or ischemic HF but not in controls. The CS-aorta difference in adiponectin levels, which reflect cardiac release of adiponectin, positively correlated with PV levels in patients with either non-ischemic HF or ischemic HF. The CS-aorta difference in adiponectin levels positively correlated with PV levels of brain natriuretic peptide and inversely with LVEF in patients with either non-ischemic HF or ischemic HF. CONCLUSIONS: Adiponectin is released from the heart into the peripheral circulation in proportion to the extent of LV dysfunction in patients with HF irrespective of etiologies of HF.
Hajime Takano; Jyun-ei Obata; Yasushi Kodama; Yoshinobu Kitta; Takamitsu Nakamura; Akira Mende; Ken-ichi Kawabata; Yukio Saito; Daisuke Fujioka; Tsuyoshi Kobayashi; Toshiaki Yano; Keita Sano; Kiyotaka Kugiyama
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-14
Journal Detail:
Title:  International journal of cardiology     Volume:  132     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Department of Internal Medicine II, University of Yamanashi, Chuo City, Yamanashi Prefecture, Japan.
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MeSH Terms
Adiponectin / blood*,  secretion*
Heart Failure / blood*
Middle Aged
Myocardium / secretion*
Reg. No./Substance:

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