| Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats. | |
| | |
MedLine Citation:
|
PMID: 21521713 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of the paper is to investigate the effects of adiponectin in diabetic nephropathy; we used an adenovirus to over-express adiponectin (Ad-Adipo) in streptozotocin (STZ)-induced diabetic rats. Animals were injected with either Ad-Adipo or control Ad-lacZ at 10 weeks after STZ treatment, and at two weeks postadenovirus injection, renal function was assessed. The degree of proteinuria was significantly reduced in Ad-Adipo rats compared with Ad-lacZ rats. Consistent with this, the mRNA expression levels of nephrin and transforming growth factor β (TGF-β) were significantly increased and decreased in the renal cortex of Ad-Adipo rats, respectively. Moreover, adiponectin over-expression in STZ rats decreased markers of endothelial dysfunction, a feature of diabetic nephropathy disease progression. Endothelin 1 (ET-1), plasminogen activator inhibitor 1 (PAI-1) and inducible nitric oxide synthase (iNOS) mRNA expression levels were significantly reduced in the renal cortex of Ad-Adipo rats, respectively. Concurrently, mRNA expression levels of endothelial nitric oxide synthase (eNOS), a positive regulator of endothelial function, were significantly increased in the renal cortex of Ad-Adipo rats. We have shown that chronic hyperadiponectinemia significantly alleviated the progression of proteinuria in early stage diabetic nephropathy. The mechanism whereby adiponectin decreases proteinuria involves an increase in nephrin expression, and an improvement of the endothelial dysfunction due to decreases in ET-1 and PAI-1, and an increase in eNOS expression in the renal cortex. Thus, over-expression of adiponectin has beneficial effects on early stage diabetic nephropathy. |
| | |
Authors:
|
Shintaro Nakamaki; Hiroaki Satoh; Akihiro Kudoh; Yoshimitsu Hayashi; Hiroyuki Hirai; Tsuyoshi Watanabe |
Related Documents
:
|
18699743 - Clinical application of emerging sensor technologies in diabetes management: consensus ... 6316003 - Diagnostic monitoring of plasma levels of glucose and insulin during surgery for insuli... 1830533 - Human insulin use and hypoglycaemia: insights from the pittsburgh epidemiology of diabe... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-26 |
Journal Detail:
|
Title: Experimental biology and medicine (Maywood, N.J.) Volume: - ISSN: 1535-3699 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, 1 Hikarigaoka, Fukushima-City, Fukushima 960-1295, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vascular rhexis in mice subjected to non-sustained myocardial ischemia and its therapeutic implicati...
Next Document: Premature aging with impaired oxidative stress defense in mice lacking TR4.