| Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism. | |
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MedLine Citation:
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PMID: 15650029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adipocytokines are bioactive peptides that may play an important role in the regulation of glucose and lipid metabolism. In this study, we investigated the association of plasma adipocytokine concentrations with markers of triglyceride-rich lipoprotein (TRL) metabolism in men. METHODS: Fasting adiponectin, leptin, resistin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), apolipoprotein (apo) B-48, apo C-III, and remnant-like particle (RLP)-cholesterol concentrations were measured by immunoassays and insulin resistance by homeostasis assessment (HOMA) score in 41 nondiabetic men with a body mass index of 22-35 kg/m2. Visceral and subcutaneous adipose tissue masses (ATMs) were determined by magnetic resonance imaging and total ATM by bioelectrical impedance. RESULTS: In univariate regression, plasma adiponectin and leptin concentrations were inversely and directly associated with plasma apoB-48, apoC-III, RLP-cholesterol, triglycerides, VLDL-apoB, and VLDL-triglycerides (P <0.05). Resistin, IL-6, and TNF-alpha were not significantly associated with any of these variables, except for a direct correction between apoC-III and IL-6 (P <0.05). In multivariate regression including HOMA, age, nonesterified fatty acids, and adipose tissue compartment, adiponectin was an independent predictor of plasma apoB-48 (beta coefficient = -0.354; P = 0.048), apoC-III (beta coefficient = -0.406; P = 0.012), RLP-cholesterol (beta coefficient = -0.377; P = 0.016), and triglycerides (beta coefficient = -0.374; P = 0.013). By contrast, leptin was not an independent predictor of these TRL markers. Plasma apoB-48, apoC-III, RLP-cholesterol, and triglycerides were all significantly and positively associated with plasma insulin, HOMA, and visceral, subcutaneous, and total ATMs (P <0.05). CONCLUSIONS: These data suggest that the plasma adiponectin concentration may not only link abdominal fat, insulin resistance, and dyslipidemia, but may also exert an independent role in regulating TRL metabolism. |
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Authors:
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Dick C Chan; Gerald F Watts; Theodore W K Ng; Yoshiaki Uchida; Naohiko Sakai; Shizuya Yamashita; P Hugh R Barrett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2005-01-13 |
Journal Detail:
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Title: Clinical chemistry Volume: 51 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-01 Completed Date: 2005-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: United States |
Other Details:
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Languages: eng Pagination: 578-85 Citation Subset: IM |
Affiliation:
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School of Medicine and Pharmacology, Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin Adipose Tissue / metabolism Adult Analysis of Variance Apolipoprotein B-48 Apolipoprotein C-III Apolipoproteins B / blood Apolipoproteins C / blood Biological Markers / blood Cholesterol / blood Cytokines / blood* Homeostasis Hormones, Ectopic / blood Humans Insulin Resistance Intercellular Signaling Peptides and Proteins / blood* Interleukin-6 / blood Leptin / blood Lipoproteins / blood, metabolism* Magnetic Resonance Imaging Male Middle Aged Predictive Value of Tests Regression Analysis Resistin Triglycerides / blood, metabolism* Tumor Necrosis Factor-alpha / analysis |
| Grant Support | |
ID/Acronym/Agency:
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P41 EB-001975/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Apolipoprotein B-48; 0/Apolipoprotein C-III; 0/Apolipoproteins B; 0/Apolipoproteins C; 0/Biological Markers; 0/Cytokines; 0/Hormones, Ectopic; 0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-6; 0/Leptin; 0/Lipoproteins; 0/RETN protein, human; 0/Resistin; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha; 0/remnant-like particle cholesterol; 57-88-5/Cholesterol |
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