| Adiponectin is a link among inflammation, insulin resistance, and high-density lipoprotein cholesterol but is not associated with paraoxonase activity in premenopausal women. | |
| | |
MedLine Citation:
|
PMID: 19878382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to evaluate whether insulin sensitivity, inflammatory response, and plasma lipid profile are associated with circulating adiponectin levels in nondiabetic healthy women. The authors also assessed whether adiponectin has any effect on high-density lipoprotein cholesterol-linked paraoxonase 1 (PON-1) activity and on the susceptibility of low-density lipoproteins to oxidation. Plasma adiponectin was measured in 91 nondiabetic premenopausal women, and the patients were then divided into quartiles. Circulating adiponectin was found to be associated with body mass index (r=.55, P<.001). After adjustment for body mass index, adiponectin showed an inverse correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.41, P<.001) and a positive correlation with high-density lipoprotein cholesterol (r=.43, P<.001). In linear regression analysis, HOMA-IR, tumor necrosis factor alpha, and high-density lipoprotein cholesterol levels were found to be independently associated with adiponectin. However, high-density lipoprotein cholesterol-linked PON-1 activity and the susceptibility of low-density lipoproteins to in vitro oxidation did not seem to be related to plasma adiponectin concentrations. |
| | |
Authors:
|
Pinar Cetinalp-Demircan; Selda Bekpinar; Figen Gurdol; Yusuf Orhan |
Publication Detail:
|
Type: Evaluation Studies; Journal Article |
Journal Detail:
|
Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 11 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-11-02 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
|
Languages: eng Pagination: 672-7 Citation Subset: IM |
Copyright Information:
|
2009 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Biochemistry, Istanbul University, Capa, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adiponectin
/
blood* Adult Aryldialkylphosphatase / blood* Blood Pressure / physiology Body Mass Index Cholesterol, HDL / blood* Female Homeostasis / physiology Humans Inflammation / physiopathology* Insulin Resistance / physiology* Linear Models Middle Aged Premenopause / blood*, physiology* Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
|
0/Adiponectin; 0/Cholesterol, HDL; 0/Tumor Necrosis Factor-alpha; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predicting postprandial lipemia in healthy adults and in at-risk individuals with components of the ...
Next Document: Vascular function measured by fingertip thermal reactivity is impaired in patients with metabolic sy...