| Adiponectin levels and its role in insulin resistance among adult women with metabolic syndrome. | |
| | |
MedLine Citation:
|
PMID: 21063038 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
AIM: To identify the proportion of low adiponectin level and to evaluate the role of low adiponectin level, age, body mass index, and waist circumference on the occurrence of metabolic syndrome in women with insulin resistance. METHODS: The study was done by a cross-sectional survey on adult women aged 30-60 years. The study was conducted at Fatmawati Hospital-Jakarta from January to March 2008 with a total sample of 33. The sample was selected consecutively based on the presence of metabolic syndrome according to the IDF 2005 criteria. The examination of plasma adiponectin level was done by ELISA method. Insulin resistance was defined if HOMA IR > or = 2 (calculated by fasting insulin (microU/mL) x Fasting blood sugar (mmol/L) divided by 22.5). Association of low adiponectin level with insulin resistance was evaluated by calculating the Odds Ratio. RESULTS: Seventeen of 33 subjects with metabolic syndrome have insulin resistance, in which 7 of them (41.18%) show low adiponectin level. While in 16 subjects without insulin resistance, only one subject (6.25%) has low adiponectin level. From 8 subjects with low adiponectin level, 7 of them (87.5%) have insulin resistance. In other words, low adiponectin level is associated with increased risk of insulin resistance (Odds Ratio 10.5, P = 0.040 (CI 95% : 1.12-98.91). CONCLUSION: Low adiponectin concentration increases the risk of developing insulin resistance much more than normal adiponectin level. |
| | |
Authors:
|
Nanang Soebijanto; Sarwono Waspadji |
Related Documents
:
|
12824788 - Serum adipocytokines are related to lipodystrophy and metabolic disorders in hiv-infect... 12403078 - The function of leptin in nutrition, weight, and physiology. 19559298 - The association between adiponectin/leptin ratio and diabetes type: the search for diab... 18467448 - Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resi... 648748 - Neurotensin hyperglycemia:evidence for histamine mediation and the assessment of a poss... 14633808 - In utero dietary exposures and risk of islet autoimmunity in children. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta medica Indonesiana Volume: 42 ISSN: 0125-9326 ISO Abbreviation: Acta Med Indones Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7901042 Medline TA: Acta Med Indones Country: Indonesia |
Other Details:
|
Languages: eng Pagination: 187-91 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Fatmawati Hospital, Jl. RS Fatmawati, Jakarta 12430, Indonesia. nsoebi@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolic syndrome.
Next Document: Relationship of angiotensin converting enzyme gene polymorphism and hypertension in Yogyakarta, Indo...