| Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study. | |
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MedLine Citation:
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PMID: 20189560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of metformin in polycystic ovary syndrome (PCOS). As follow-up on a previous paper describing hormonal and metabolic factors, this paper focuses on correlations between adiponectin and anthropometric, hormonal, and metabolic factors in PCOS and the effect of metformin. DESIGN: Randomized, double-blind, placebo-controlled crossover study. SETTING: District and university hospital. PATIENT(S): Fifty-two women with PCOS. Three groups were defined according to baseline adiponectin. INTERVENTION(S): Metformin or placebo for 6 months, followed by 3 months' washout before switching to opposite treatment. Blood tests and measurements were performed before and after treatment periods. MAIN OUTCOME MEASURE(S): Adiponectin, insulin, homeostasis model assessment (HOMA) index, and testosterone. RESULT(S): Waist-hip ratio (WHR), insulin, and HOMA index were significantly higher in the lower adiponectin group than in the upper and middle group, and high-density lipoprotein (HDL) cholesterol was higher in the upper than in the lower adiponectin group. Multiple regression analysis with adiponectin as the dependent variable and HOMA index, HDL cholesterol, testosterone, and WHR as independent variables showed an R(2) of 0.43 with β-coefficients of -0.12 for the HOMA index, 0.72 for HDL cholesterol, and -1.49 for WHR. Testosterone did not contribute to the prediction of adiponectin levels. Metformin had no effect on adiponectin in spite of significant decreases in weight, fasting glucose, and insulin resistance. CONCLUSION(S): In PCOS, adiponectin levels are closely linked to insulin resistance, HDL cholesterol, and abdominal adiposity and unaffected by metformin. |
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Authors:
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Birgitta Trolle; Finn Friis Lauszus; Jan Frystyk; Allan Flyvbjerg |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-03-02 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-12-08 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2234-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynaecology, Aarhus University Hospital, Skejby, Denmark. ditte.trolle@dadlnet.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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analysis,
blood Adolescent Adult Cross-Over Studies Double-Blind Method Female Humans Hypoglycemic Agents / pharmacology, therapeutic use Insulin / blood Insulin Resistance / physiology Metformin / pharmacology*, therapeutic use* Middle Aged Placebos Polycystic Ovary Syndrome / blood*, drug therapy*, metabolism Testosterone / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Hypoglycemic Agents; 0/Insulin; 0/Placebos; 58-22-0/Testosterone; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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