| Adiponectin level and left ventricular hypertrophy in Japanese men. | |
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MedLine Citation:
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PMID: 17420337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A recent study has demonstrated that adiponectin inhibited hypertrophic signaling in the myocardium of mice, implying that a decrease in the blood adiponectin level could cause cardiac muscle hypertrophy. We hypothesized that a relationship might exist between the serum adiponectin level and electrocardiographically diagnosed left ventricular hypertrophy (ECG-LVH), and we examined this hypothesis by epidemiological study of 2839 Japanese male workers who were not taking medications for hypertension. ECG-LVH was defined as meeting Sokolow-Lyon voltage criteria and/or Cornell voltage-duration product. The subjects were categorized by tertiles of serum adiponectin level, and a multivariate logistic regression analysis was conducted relating left ventricular hypertrophy to adiponectin tertiles adjusting for potential confounding factors. Prevalence of ECG-LVH in the studied sample was 16.7%. Adiponectin ranged from 1.0 to 5.0 microg/mL in the lowest category and from 7.4 to 30.6 microg/mL in the highest. Compared with subjects in the highest adiponectin category, those in the lowest one had a significantly higher prevalence of ECG-LVH independent of age, body mass index, and systolic blood pressure with an odds ratio of 1.50 and a 95% CI of 1.16 to 1.94. Further adjustment for high-density lipoprotein cholesterol, triglyceride, and insulin resistance did not change the association (odds ratio: 1.68; 95% CI: 1.28 to 2.21; P<0.001). Similar results were obtained when different criteria for ECG-LVH were used or when subjects were stratified by blood pressure or body mass index. Adiponectin concentration was inversely and independently associated with ECG-LVH in Japanese men. |
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Authors:
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Hirotsugu Mitsuhashi; Hiroshi Yatsuya; Koji Tamakoshi; Kunihiro Matsushita; Rei Otsuka; Keiko Wada; Kaichiro Sugiura; Seiko Takefuji; Yo Hotta; Takahisa Kondo; Toyoaki Murohara; Hideaki Toyoshima |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-09 |
Journal Detail:
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Title: Hypertension Volume: 49 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-24 Completed Date: 2007-06-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 1448-54 Citation Subset: IM |
Affiliation:
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Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood*,
physiology Adult Aged Body Mass Index Electrocardiography Humans Hypertrophy, Left Ventricular / blood*, epidemiology*, physiopathology Japan / epidemiology Logistic Models Male Middle Aged Odds Ratio Prevalence |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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