Document Detail


Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis.
MedLine Citation:
PMID:  22852746     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective. The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction. Material and methods. In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured. Results. Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer. Conclusion. Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.
Authors:
Maria do Sameiro Faria; Sandra Ribeiro; Henrique Nascimento; Petronila Rocha-Pereira; Vasco Miranda; Denisa Mendonça; Alexandre Quintanilha; Elísio Costa; Luís Belo; Alice Santos-Silva
Related Documents :
16451286 - Hyperlipidaemia and outcome in acute pancreatitis.
2573956 - Selective surgical management of correctable hypergastrinemia.
12091856 - How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?
6852626 - Serum isoamylase as a test for pancreatic insufficiency.
1807526 - Posterior cervical fusion with triple-wire strut graft technique: one hundred consecuti...
15888786 - Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue i...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-2
Journal Detail:
Title:  Scandinavian journal of urology and nephrology     Volume:  -     ISSN:  1651-2065     ISO Abbreviation:  Scand. J. Urol. Nephrol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0114501     Medline TA:  Scand J Urol Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
FMC, Dinefro - Diálises e Nefrologia - SA , Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Note: Low temperature superconductor superconducting quantum interference device system with wide pi...
Next Document:  Radon emissions related to the granitic Precambrian shield in southern Brazil.