| Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis. | |
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MedLine Citation:
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PMID: 22852746 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective. The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction. Material and methods. In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured. Results. Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer. Conclusion. Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients. |
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Authors:
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Maria do Sameiro Faria; Sandra Ribeiro; Henrique Nascimento; Petronila Rocha-Pereira; Vasco Miranda; Denisa Mendonça; Alexandre Quintanilha; Elísio Costa; Luís Belo; Alice Santos-Silva |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-2 |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: - ISSN: 1651-2065 ISO Abbreviation: Scand. J. Urol. Nephrol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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FMC, Dinefro - Diálises e Nefrologia - SA , Portugal. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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