Document Detail


Adiponectin - An independent marker of coronary artery disease occurrence rather than a degree of its advancement in comparison to the IMT values in peripheral arteries.
MedLine Citation:
PMID:  22269158     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the study was to establish whether adiponectin may act as an independent risk factor of coronary artery disease (CAD) and if adiponectin has potential relations with a new marker of cardiovascular risk -intima-media thickness (IMT). METHODS: 165 patients, who had undergone coronary angiography due to symptoms of CAD were enrolled. Selected clinical and biochemical risk factors were assessed, adiponectin concentrations and IMT were measured. RESULTS: A significantly lower adiponectin concentrations in the CAD group, as compared to the controls, were found. Adiponectin concentration did not correlate with a degree of coronary vessels changes advancement. No correlation between adiponectin concentrations and IMT values in the studied peripheral arteries were found. The value of 9.8ug/ml has been assigned as a cut-off value. Adiponectin concentrations <9.8μg/ml had the highest positive predictive value (PPV=95.7%) and specificity (90.9), but low sensitivity (30.8). In the multilogistic regression analysis significant variables influencing the appearance of CAD were found: HDL-C (p=0.011, OR=0.88, 95%CI 0.80-0.97), IMT in CCA (p=0.0048, OR=5.25, 95%CI 1.65-16.75), IMT in CFA (p=0.015, OR=1.65, 95%CI 1.10-2.48 ), and adiponectin concentration <9.8μg/ml (p=0.032, OR=28.95, 95%CI 1.31-641.48). CONCLUSIONS: Adiponectin is an independent risk factor of coronary artery disease occurrence, but not its advancement. No correlation between adiponectin concentration and IMT values in peripheral arteries was shown.
Authors:
A Lisowska; A Tycinska; M Knapp; R Sawicki; P Lisowski; W J Musiał; S Dobrzycki
Related Documents :
1598748 - Aldosteronoma coexisting with renal artery stenosis in secondary hypertension.
17463198 - Is incidental renal arteriography justified in a population of patients with symptomati...
8414758 - Fibromuscular dysplasia with clotted renal artery aneurysm.
19031658 - Assessment and significance of arterial stiffness in patients with chronic kidney disease.
20409728 - Aortic arch surgery using bilateral antegrade selective cerebral perfusion in combinati...
17948178 - Accurate course and relationships of the intraorbital part of the ophthalmic artery in ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-16
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Department of Cardiology, Medical University of Białystok, Poland, ul. Sklodowskiej- Curie 24 A, 15-276 Bialystok, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fast and simple LC-MS/MS method for quantifying plasma voriconazole.
Next Document:  Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease.