Document Detail


Adiponectin in human cord blood: relation to fetal birth weight and gender.
MedLine Citation:
PMID:  14671149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The aim of this study was to examine whether adiponectin is present in human fetal blood, to define its association with fetal birth weight, and to evaluate whether dynamic changes in adiponectin levels occur during the early neonatal period. Cord blood adiponectin levels were extremely high (71.0 +/- 21.0 microg/ml; n = 51) compared with serum levels in children and adults and positively correlated with fetal birth weights (r = 0.4; P < 0.01). No significant differences in adiponectin levels were found between female and male neonates. In addition, there was no correlation between cord adiponectin levels and maternal body mass index, cord leptin, or insulin levels. Cord adiponectin levels were significantly higher compared with maternal levels at birth (61.1 +/- 19.0 vs. 17.6 +/- 4.9 microg/ml; P < 0.001; n = 17), and no correlation was found between cord and maternal adiponectin levels. There were no significant differences between adiponectin levels at birth and 4 d postpartum (61.1 +/- 19.0 vs. 63.8 +/- 22.0 microg/ml; n = 17). These findings indicate that adiponectin in cord blood is derived from fetal and not from placental or maternal tissues. The high adiponectin levels in newborns compared with adults may be due to lack of negative feedback on adiponectin production resulting from lack of adipocyte hypertrophy, low percentage of body fat, or a different distribution of fat depots in the newborns.
Authors:
Eyal Sivan; Shali Mazaki-Tovi; Clara Pariente; Yael Efraty; Eyal Schiff; Rina Hemi; Hannah Kanety
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  88     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-12     Completed Date:  2004-01-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5656-60     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel 52621.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin
Aging / blood
Birth Weight*
Female
Fetal Blood*
Humans
Infant, Newborn
Insulin / blood
Intercellular Signaling Peptides and Proteins*
Leptin / blood
Male
Parturition
Proteins / metabolism*
Sex Characteristics*
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins; 0/Leptin; 0/Proteins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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