| Adiponectin expression and metabolic markers in obesity and Type 2 diabetes. | |
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MedLine Citation:
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PMID: 20651470 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Adiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxisome proliferator-activated receptor- γ (PPAR-γ) plays an important, and beneficial, role in modulating adiponectin expression. AIM: The aim of the present study was to assess the separate role of obesity and Type 2 diabetes in the relationship between endogenous PPAR-γ signaling and adiponectin expression in subcutaneous adipose tissue. SUBJECTS AND METHODS: Enzyme-linked immuno sor bent assay and real time quantitative PCR analysis were carried out in overweight, obese, and/or diabetic Tunisian patients who underwent an abdominal surgery. RESULTS: These results collectively indicate that circulating levels of adiponectin were decreased in all overweight, obese, and/or diabetic (p<0.001). However, the subcutaneous mRNA expression of adiponectin was reduced only in diabetics (p<0.01) but presents some discrepancies in obese individuals. Moreover, mRNA levels of adiponectin were positively correlated with levels of mRNA encoding PPARγ and its heterodimeric partner retinoid X receptor-α (RXR-α), in both obese and diabetic patients. CONCLUSION: Our study on Tunisian patients shows impaired regulation of circulating and mRNA adiponectin levels dependent of metabolic disorders in obesity and Type 2 diabetes. The data suggest that subcutaneous adipose tissue may play an important role in modulating adiponectin expression in diabetes and obesity. Moreover, adiponectin mRNA could be potentially regulated by endogenous PPARγ/RXRα-dependent pathways. |
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Authors:
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S Kouidhi; S Jarboui; R Marrakchi; M-S Clerget Froidevaux; I Seugnet; H Abid; F Bchir; M Brahem; B Demeneix; H Guissouma; A Benammar Elgaaied |
Publication Detail:
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Type: Journal Article Date: 2010-07-22 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 34 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: e16-23 Citation Subset: IM |
Affiliation:
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Laboratory of Genetics, Immunology and Human Pathology, Biology Department, Faculté Des Sciences de Tunis, CAMPUS, El Manar University, Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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