Document Detail

Adiponectin is associated with serum and adipose tissue fatty acid composition in rats.
MedLine Citation:
PMID:  19474526     Owner:  NLM     Status:  MEDLINE    
The objective of the present work is to analyse the relationships between changes in adiponectin and fatty acid composition in serum and adipose tissue in rats. Samples from serum and different adipose depots (periovarian, mesenteric and subcutaneous) were obtained from ageing rats (14- and 20-month-old) to determine fatty acid composition (gasliquid chromatography). In serum, insulin (radioimmunoassay) and adiponectin levels (enzyme-linked immunosorbent assay) were also measured, while adiponectin gene expression was analysed (real time-qPCR) in all fat depots. There were significant age-related reductions in adipose tissue saturated (SFA) and trans fatty acids and increases in monounsaturated fatty acids in parallel with diminished adiponectin expression in periovarian and mesenteric adipose tissue (p<0.05). Age-independent negative correlations were found between adiponectin gene expression in mesenteric adipose tissue and C12:0, C14:0 and C18:2 trans fatty acids (p<0.05). There was a positive association between serum adiponectin and adipose tissue oleic acid, while palmitoleic acid was negatively associated with adiponectin expression and positively correlated with insulin concentration. For the first time, positive relationships are reported between the proportion of n-6 polyunsaturated fatty acids (PUFA) in adipose tissue and adiponectin concentration and expression. In summary, adiponectin expression and serum levels are associated with fatty acid composition, with SFA, trans and palmitoleic fatty acids appearing as negative markers for adiponectin, and oleic acid and n-6 PUFA as positive ones. In addition, most associations were found in the visceral depots, highlighting the importance of visceral fat in the metabolic status.
F Pérez de Heredia; J Sánchez; T Priego; E Larqué; M del Puy Portillo; A Palou; S Zamora; M Garaulet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-01
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  32     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-11-26     Completed Date:  2010-01-20     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  659-65     Citation Subset:  IM    
Dept. Physiology, University of Murcia, Paseo Rector Sabater s/n, Campus de Espinardo, 30100 Murcia, Spain.
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MeSH Terms
Adipocytes / metabolism
Adiponectin / metabolism*
Adipose Tissue / metabolism*
Aging / physiology*
Dietary Fats / administration & dosage
Fatty Acids / metabolism*
Fatty Acids, Monounsaturated / metabolism
Fatty Acids, Unsaturated / metabolism
Gene Expression
Insulin / blood
Intra-Abdominal Fat / metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Adiponectin; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Insulin

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