| Adiponectin and arterial stiffness. | |
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MedLine Citation:
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PMID: 16364823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adiponectin, an anti-inflammatory adipocytokine, is reduced in hypertension, diabetes, and coronary artery disease (CAD). Arterial stiffness, as aortic pulse wave velocity (PWV) in hypertension and diabetes, and as augmentation index (AIx) in CAD, is independently associated with cardiovascular mortality. We explored the relationship between adiponectin and arterial stiffness in essential hypertension. METHODS: Seventy-six untreated patients, 34 women, aged 47 +/- 1 years, mean +/- SEM with essential hypertension, had blood pressure (BP), carotid-femoral PWV, AIx plasma adiponectin, and proinflammatory cytokine C-reactive protein (CRP) measured using ELISA technique after an overnight fast. Results were analyzed using univariate and multiple logistic regression analysis. RESULTS: There was a significant positive relationship between log adiponectin and AIx (r = 0.33, P < .005) and plasma HDL-cholesterol (r = 0.40, P < .001). In contrast there were significant negative relationships with PWV (r = -0.24, P < .05), transit time (r = -0.37, P < .001), and pulse pressure amplification (r = -0.30, P < .005) in addition to waist circumference, waist-to-hip ratio, height, and weight. In a stepwise regression model, the independent predictors of AIx were heart rate, height, mean arterial pressure, age, and gender (R2= 0.69, P < .0001) with no contribution from adiponectin. However, for PWV (R2= 0.59, P < .0001) the independent determinants were mean arterial pressure, age, and adiponectin. CONCLUSIONS: These results show a divergent relationship between adiponectin and arterial stiffness, negative for PWV, and positive for wave reflection (AIx). Anthropomorphic factors, particularly height, weight, and heart rate may influence the relationship to the latter. Adiponectin is an independent predictor of aortic PWV but not of AIx. |
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Authors:
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Azra Mahmud; John Feely |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 18 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-20 Completed Date: 2006-09-14 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 1543-8 Citation Subset: IM |
Affiliation:
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Department of Therapeutics and Hypertension Clinic, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adult Aorta / physiopathology Arteries / physiopathology* Blood Flow Velocity Body Height Body Weight Carotid Arteries / physiopathology Cholesterol, HDL / blood Elasticity Female Femoral Artery / physiopathology Heart Rate Humans Hypertension / blood*, physiopathology Male Middle Aged Pulsatile Flow Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Cholesterol, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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