Document Detail

Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  19648128     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adiponectin is an adipose-derived plasma protein that exhibits beneficial actions on the heart. Recently, it was shown that adiponectin levels were elevated in patients with systolic heart failure. OBJECTIVE: To investigate the association between adiponectin levels and left ventricular (LV) diastolic function in patients with hypertrophic cardiomyopathy (HCM), characterised by diastolic dysfunction. METHODS: Twenty-six patients with HCM showing LV ejection fraction of >60% were enrolled. LV pressure half-time (T(1/2)) was measured as an index of myocardial relaxation. Patients were divided into two groups on the basis of baseline T(1/2) (group A: T(1/2)< 35 ms, group B: T(1/2) > or = 35 ms). Blood samples were simultaneously collected from the coronary sinus (CS) and aortic root (Ao) as well as the peripheral vein (PV) for measurement of plasma adiponectin levels. RESULTS: Plasma adiponectin levels were significantly higher in group B than in group A. Adiponectin levels in the PV were positively correlated with the baseline T(1/2) in patients with HCM. The transcardiac gradient of adiponectin as calculated by the Ao-CS difference was significantly higher in group A than in group B. The transcardiac gradient of adiponectin also inversely correlated with the baseline T(1/2) and adiponectin levels in PV in patients with HCM. The expression of AdipoR1 but not AdipoR2 in the heart decreased in group B. The baseline T(1/2) was negatively associated with AdipoR1 expression in patients with HCM. CONCLUSIONS: These data document that adiponectin is an indicator of LV diastolic dysfunction in patients with HCM.
Kazumasa Unno; Rei Shibata; Hideo Izawa; Akihiro Hirashiki; Yosuke Murase; Takashi Yamada; Masakazu Kobayashi; Akiko Noda; Kohzo Nagata; Noriyuki Ouchi; Toyoaki Murohara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-30
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-06-15     Revised Date:  2010-09-20    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-61     Citation Subset:  AIM; IM    
Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya 466-8550, Japan.
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MeSH Terms
Adiponectin / blood*
Aorta, Thoracic / metabolism
Biological Markers / blood
Cardiomyopathy, Hypertrophic / blood*
Coronary Sinus / metabolism
Diastole / physiology
Hypertrophy, Left Ventricular / blood*
Middle Aged
Stroke Volume / physiology
Veins / metabolism
Ventricular Dysfunction, Left / blood*
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers
Comment In:
Heart. 2010 Oct;96(19):1605; author reply 1605   [PMID:  20702538 ]
Heart. 2010 Mar;96(5):331-2   [PMID:  19934101 ]

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