| Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy. | |
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MedLine Citation:
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PMID: 20537918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Adipokines play an important role in metabolic regulations. Obesity, diabetes, and renal disturbances affect adipokine profile by influencing their complex effects on metabolism. Our objective was to assess the effect of low-energy diet intervention on serum adiponectin, leptin, and resistin levels in diabetic nephropathy. METHODS: Seventeen subjects with diabetes type 2 and nephropathy participated in the study. After estimation of individual resting metabolic rates by indirect calorimetry, diets introducing 20% energy deficit were applied. At baseline and after 2 months of dieting, the following parameters were measured: body composition by dual x-ray spectrometry and serum adiponectin (Adp), leptin (Lep), resistin (Res), insulin, urea, creatinine, glucose, glycosylated hemoglobin, C-reactive protein, and tumor necrosis factor-alpha concentrations. Homeostatic model assessment (HOMA) was used to quantify insulin resistance. RESULTS: Total energy, protein, and fat intakes diminished significantly with intentional dieting. Significant decreases in total body fat mass (FM) and its percentage in body mass (FM%) and trunk and gynoid fat mass, as well as in serum resistin and tumor necrosis factor-alpha levels, were also observed. Responses of adipokines to dietary treatment varied individually. Generally, they were affected by FM. Alterations in Lep concentrations correlated negatively with baseline FM, FM%, and android and gynoid fat mass and positively with changes in intake of protein, carbohydrates, and total energy of the consumed diet. Changes in Adp were inversely related to FM after therapy. Alterations in Res concentrations correlated positively with android fat mass before therapy and initial Lep levels. Adiponectin was inversely related to HOMA index before and after treatment. CONCLUSIONS: Low-energy diet applied in diabetic nephropathy may decrease serum resistin levels and inflammation. In addition, responses of all adipokines to dieting appear to be affected by body fat mass, especially android fat mass. |
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Authors:
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Lucyna Kozłowska; Andrzej Rydzewski; Bartosz Fiderkiewicz; Anna Wasińska-Krawczyk; Agnieszka Grzechnik; Danuta Rosołowska-Huszcz |
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Publication Detail:
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Type: Journal Article Date: 2010-05-26 |
Journal Detail:
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Title: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation Volume: 20 ISSN: 1532-8503 ISO Abbreviation: J Ren Nutr Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112938 Medline TA: J Ren Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 255-62 Citation Subset: IM |
Copyright Information:
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Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, 02-776 Warsaw, Poland. lucyna_kozlowska@sggw.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adipose Tissue / metabolism Aged Blood Glucose / analysis, metabolism Body Composition C-Reactive Protein / metabolism Calorimetry, Indirect Creatinine / blood Diabetes Mellitus, Type 2 / blood, complications, diet therapy Diabetic Nephropathies / blood*, diet therapy* Diet, Reducing* Dietary Carbohydrates / administration & dosage Dietary Fats / administration & dosage Energy Intake Female Humans Inflammation / blood Leptin / blood* Male Resistin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Leptin; 0/Resistin; 60-27-5/Creatinine; 9007-41-4/C-Reactive Protein |
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