Document Detail


Adiponectin and hypertension.
MedLine Citation:
PMID:  20930707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adipose tissue secretes a variety of bioactive molecules, also known as adipocytokines or adipokines. Obesity, in particular, visceral fat accumulation, is implicated in the dysregulated secretion of adipocytokines, which can contribute to the development of metabolic syndrome and cardiovascular diseases. Adiponectin is an adipocytokine that is exclusively secreted from adipose tissue, but its plasma levels are reduced in obese subjects, especially those with visceral fat accumulation. Adiponectin has a variety of protective properties against obesity-linked complications, such as hypertension, metabolic dysfunction, atherosclerosis, and ischemic heart disease. Adiponectin exerts the beneficial effects on vascular disorders by directly affecting components of vascular tissue. This review will discuss clinical and experimental findings that examine the role of adiponectin in regulation of hypertension and vascular function.
Authors:
Koji Ohashi; Noriyuki Ouchi; Yuji Matsuzawa
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-07
Journal Detail:
Title:  American journal of hypertension     Volume:  24     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-15     Completed Date:  2011-06-15     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood,  physiology*
Animals
Biological Markers
Cyclooxygenase 2 / physiology
Endothelium, Vascular / physiology
Humans
Hypertension / blood,  physiopathology,  prevention & control*
Macrophages / physiology
Nitric Oxide / biosynthesis
Renin-Angiotensin System / physiology
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 10102-43-9/Nitric Oxide; EC 1.14.99.1/Cyclooxygenase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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