Document Detail

Adiponectin gene polymorphisms are associated with long-chain ω3-polyunsaturated fatty acids in serum phospholipids in nondiabetic Koreans.
MedLine Citation:
PMID:  20685864     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Hypoadiponectinemia is caused by interactions between genetic and environmental factors, including the quality of dietary fats.
OBJECTIVE: We investigated the association of single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) with dietary fat intake or fatty acid (FA) composition in serum phospholipids, plasma adiponectin, and insulin resistance.
METHODS: Nondiabetic subjects (n = 1194) were genotyped for three ADIPOQ SNPs (-11377C>G; 45T>G; 276G>T) after screening of eight sites. Dietary fat intake, FA composition in serum phospholipids, adiponectin, and homeostasis model assessment of insulin resistance (HOMA-IR) were also measured.
RESULTS: The 276G carriers (n = 1082) showed lower high-density lipoprotein cholesterol (P = 0.024) and adiponectin (P < 0.001) but higher glucose (P = 0.015) and HOMA-IR (P = 0.005) than 276T/T subjects (n = 112). No associations were found in other SNPs. After adjusted for age, sex, body mass index, and the proportion of 18:2ω6 and 18:3ω3 (biomarkers of long term essential FA intake), the 276G carriers showed lower proportions of total ω3FA (P = 0.026), 20:5ω3 (P = 0.021), and 22:5ω3 (P = 0.024) in serum phospholipids. Among FAs in serum phospholipids, 18:2ω6 highly correlated with ω3-polyunsaturated FA (PUFA) intake (r = 0.260, P < 0.001) and adiponectin (r = 0.150, P < 0.001). The 276G carriers with a higher proportion of 18:2ω6 (≥12.5%) exhibited more pronounced characteristics, i.e. lower adiponectin (P < 0.001), lower high-density lipoprotein cholesterol (P = 0.004), higher HOMA-IR (P = 0.013), and lower long-chain ω3PUFAs (20:5ω3, 22:5ω3, and 22:6ω3, P < 0.001). Additionally, the effect of 276G>T on the relationship between adiponectin and HOMA-IR was modified by 18:2ω6 proportion.
CONCLUSION: ADIPOQ 276G is associated with reduced proportion of long-chain ω3PUFAs in serum phospholipids in nondiabetic Koreans.
Bumsik Kim; Yangsoo Jang; Jean Kyung Paik; Oh Yoen Kim; Sang-Hak Lee; Jose M Ordovas; Jong Ho Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-04
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E347-51     Citation Subset:  AIM; IM    
Interdisciplinary Course of Science for Aging, Cardiovascular Genome Center and Severance Medical Research institute, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Adiponectin / blood,  genetics*
Analysis of Variance
Asian Continental Ancestry Group / genetics
Blood Glucose
Dietary Fats
Fatty Acids, Omega-3 / blood*,  genetics
Gene Frequency
Genetic Association Studies
Insulin Resistance / genetics
Phospholipids / blood*,  genetics
Polymorphism, Single Nucleotide*
Reg. No./Substance:
0/Adiponectin; 0/Blood Glucose; 0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Phospholipids

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