| Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. | |
| | |
MedLine Citation:
|
PMID: 19850745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aldosterone infusion results in left ventricular hypertrophy (LVH) and hypertension and may involve profibrotic and proinflammatory mechanisms. In turn, hypertension is the major cause of diastolic heart failure (HF). Adiponectin, an adipose-derived plasma protein, exerts antiinflammatory and anti-hypertrophic effects and is implicated in the development of hypertension and systolic HF. We thus tested the hypothesis that hypoadiponectinemia in aldosterone-induced hypertension exacerbated cardiac remodeling and diastolic HF. Wild-type (WT) or adiponectin-deficient (APNKO) mice underwent saline or aldosterone infusion and uninephrectomy and were fed 1% salt water for 4 wk. Blood pressure was increased in aldosterone-infused WT (132 +/- 2 vs. 109 +/- 3 mm Hg; P < 0.01) and further augmented in APNKO mice (140 +/- 3 mm Hg; P < 0.05 vs. aldosterone-infused WT). LVH was increased in aldosterone-infused WT vs. WT mice (LV/body weight ratio, 4.8 +/- 0.2 vs. 4.1 +/- 0.2 mg/g) and further increased in aldosterone-infused APNKO mice (LV/body weight ratio, 6.0 +/- 0.4 mg/g). Left ventricular ejection fraction was not decreased in either aldosterone-infused WT or APNKO hearts. Pulmonary congestion however was worse in APNKO mice (P < 0.01). The ratio of early ventricular filling over late ventricular filling (E/A) and the ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity (E/e'), measures of diastolic function, were increased in aldosterone-infused WT hearts and further increased in APNKO hearts (P < 0.05 for both). Renal function and cardiac fibrosis were no different between both aldosterone-infused groups. Aldosterone increased matrix metalloproteinase-2 expression in WT hearts (P < 0.05 vs. WT and P < 0.01 vs. APNKO). Myocardial atrial natriuretic peptide, interferon-gamma, and TNF-alpha expression were increased in aldosterone-infused WT hearts. Expression of these proteins was further increased in aldosterone-infused APNKO hearts. Therefore, hypoadiponectinemia in hypertension-induced diastolic HF exacerbates LVH, diastolic dysfunction, and diastolic HF. Whether or not adiponectin replacement prevents the progression to diastolic HF will warrant further study. |
| | |
Authors:
|
Flora Sam; Toni-Ann S Duhaney; Kaori Sato; Richard M Wilson; Koji Ohashi; Saki Sono-Romanelli; Akiko Higuchi; Deepa S De Silva; Fuzhong Qin; Kenneth Walsh; Noriyuki Ouchi |
Related Documents
:
|
3308975 - Intravenous pinacidil in the acute treatment of hypertension. 20102385 - Effects of raloxifene on the renin-angiotensin-aldosterone system and blood pressure in... 15229305 - Serum aldosterone and the incidence of hypertension in nonhypertensive persons. 1330385 - Plasma 19-hydroxy-androstenedione (19-oh-a) in essential hypertension. 8158885 - Renal protective effects of enalapril in hypertensive niddm: role of baseline albuminuria. 12243855 - Abnormal temporal dynamics of blood pressure and rr interval regulation in patients wit... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-22 |
Journal Detail:
|
Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-23 Completed Date: 2010-02-22 Revised Date: 2011-07-19 |
Medline Journal Info:
|
Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
|
Languages: eng Pagination: 322-31 Citation Subset: AIM; IM |
Affiliation:
|
Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA. flora.sam@bmc.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adiponectin
/
blood,
genetics,
metabolism,
physiology Animals Biological Markers / analysis, blood Blood Pressure / genetics, physiology Diastole / genetics*, physiology Echocardiography, Doppler Fibrosis Heart / anatomy & histology, physiopathology Heart Failure, Diastolic / blood, genetics*, physiopathology Hypertension / blood, complications, genetics, physiopathology Hypertrophy, Left Ventricular / genetics, metabolism, physiopathology Kidney / physiology Matrix Metalloproteinases / metabolism Mice Mice, Inbred C57BL Mice, Knockout Myocardium / metabolism, pathology Tissue Inhibitor of Metalloproteinases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
HL079099/HL/NHLBI NIH HHS; R21 HL095891-02/HL/NHLBI NIH HHS; R37 AG015052-15/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adiponectin; 0/Biological Markers; 0/Tissue Inhibitor of Metalloproteinases; 0/adiponectin, mouse; EC 3.4.24.-/Matrix Metalloproteinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellul...
Next Document: Robust Up-Regulation of Nuclear Red Fluorescent-Tagged Fos Marks Neuronal Activation in Green Fluore...