| Adiponectin and Cardiovascular Disease: Mechanisms and New Therapeutic Approaches. | |
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MedLine Citation:
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PMID: 22257055 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adiponectin is an abundant plasma protein secreted from adipocytes. Its role in energy homeostasis is well-known including the regulation of hydrocarbons and lipids metabolism as well as the improvement of insulin resistance. It has been thought to be a key molecule in the development of type 2 diabetes and metabolic syndrome, which are epidemiological targets for preventing cardiovascular disease. In addition to beneficial metabolic effects, adiponectin seems to have anti-inflammatory and vasoprotective actions. Furthermore, adiponectin affects signalling in myocardial cells and exerts beneficial actions on the heart after pressure overload and ischemia-reperfusion injury. The ability of adiponectin to reduce insulin resistance in conjunction with its anti-inflammatory and cardioprotective properties makes this adipocytokine a promising therapeutic target. On clinical interest, agents that enhance endogenous adiponectin production or action have potential for the treatment of cardiovascular disease. Management strategies that increase adiponectin levels include weight reduction, Mediterranean diet, thiazolidinediones, antihypertensive and lipid lowering drugs. Current knowledge on the regulation of adiponectin and therapeutic approaches for cardiovascular disease is summarized in this review. |
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Authors:
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G Siasos; D Tousoulis; C Kollia; E Oikonomou; Z Siasou; C Stefanadis; A G Papavassiliou |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Current medicinal chemistry Volume: - ISSN: 1875-533X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Mikras Asias 75, 115 27, Hippokration Hospital, Athens, Greece. ger_sias@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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