| Adipokines and cardiometabolic function: How are they interlinked? | |
| | |
MedLine Citation:
|
PMID: 20615436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. Most studies focus on a single adipokine. We therefore investigated the independent relationships of leptin, adiponectin, tumor necrosis factor-alpha, resistin and visfatin, as well as the gut hormone ghrelin with blood pressure and insulin resistance. Secondly we evaluated the interrelationships of adipokines and ghrelin in concert with various cardiometabolic markers. METHODS AND RESULTS: Caucasian women (N=115) with varying levels of obesity (aged 31.3 + or - 9.18 years) were included. Significant correlations of leptin, adiponectin, ghrelin and visfatin with mean arterial pressure (p<0.05) disappeared after adjustment for age, body mass index and waist circumference. But significant correlations with insulin resistance (HOMA) (for leptin, adiponectin and ghrelin) remained significant after adjustments. Factor analyses yielded five factors, but two main clusters, namely a metabolic syndrome cluster (including leptin, adiponectin and ghrelin) and a vascular atherosclerotic cluster (including tumor necrosis factor-alpha, visfatin and resistin). CONCLUSION: Factor analyses identified patterns which indicate specific roles of the various adipokines. Leptin, adiponectin and ghrelin were more closely related to insulin resistance and central obesity as core components of the metabolic syndrome. Visfatin, tumor necrosis factor-alpha and resistin seem to direct their effects onto the vascular system possibly by means of mechanisms such as inflammation, vasoconstriction and coagulation. |
| | |
Authors:
|
Aletta Elisabeth Schutte; Hugo Willem Huisman; Rudolph Schutte; Johannes Marthinus van Rooyen; Leoné Malan; Catharina Maria Theresia Fourie; Nicolaas Theodore Malan |
Related Documents
:
|
18480556 - Acarbose treatment increases serum total adiponectin levels in patients with type 2 dia... 17641276 - Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrati... 9209166 - Response of serum leptin concentrations to 7 d of energy restriction in centrally obese... 17467106 - Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabe... 8518456 - Molecular aspects of the etiology of type i diabetes mellitus. 22144496 - History of diabetes and risk of head and neck cancer: a pooled analysis from the intern... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-06 |
Journal Detail:
|
Title: Regulatory peptides Volume: 164 ISSN: 1873-1686 ISO Abbreviation: Regul. Pept. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-23 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 133-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Alta.Schutte@nwu.ac.za |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipokines
/
blood* Adiponectin / blood Adult Blood Pressure / physiology Body Mass Index Female Ghrelin / blood Humans Insulin Resistance / physiology Leptin / blood Middle Aged Nicotinamide Phosphoribosyltransferase / blood Obesity / blood Resistin / blood Tumor Necrosis Factor-alpha Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Adipokines; 0/Adiponectin; 0/Ghrelin; 0/Leptin; 0/Resistin; 0/Tumor Necrosis Factor-alpha; EC 2.4.2.12/Nicotinamide Phosphoribosyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Behavioural habituation to novelty and brain area specific immediate early gene expression in female...
Next Document: PYY(1-36) is the major form of PYY in rat distal small intestine: quantification using high-resoluti...