Document Detail

Adipokines and nutritional status for patients on maintenance hemodialysis.
MedLine Citation:
PMID:  20071195     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to investigate the serum concentration of adipokines, such as leptin, adiponectin, and resistin, and assess its relation to nutritional and inflammatory parameters in both overweight and normal weight patients on maintenance hemodialysis.
METHODS: A total of 36 hemodialysis patients (27 M, 9 F; mean age 55.3 +/- 12 yr.) were examined and 23 additional healthy volunteers were recruited as the control group. The concentrations of leptin, leptin receptor, adiponectin, resistin, IL-6, TNFa and CRP were measured by ELISA. Assessment of nutritional status was determined by the levels of albumin, BMI, percentage of body fat (%F), lean body mass (LBM), and Subjective Global Assessment Score (SGA).
RESULTS: According to the SGA 7-points score and the albumin level, 20 patients were of good nutritional status (6-7 points), while 16 patients were mildly malnourished (4-5 points). The concentrations of CRP, resistin, adiponectin, and TNFa were statistically higher in hemodialysis patients than in the control group (p pound 0.05). The adiponectin level was inversely correlated with %F (R Spearman=-0.3; p pound 0.05). The level of leptin was positively correlated with %F as well as with BMI and SGA scores (R Spearman=0.4; p pound 0.05). Although there was no significant difference in the nutritional status between the nonoverweight (BMI 18.5-24.99) and overweight (BMI (3)25.0) groups of patients, in the nonoverweight group there were 12 patients (54.5%) with signs of mild malnutrition compared to 4 malnourished patients (28.5%) in the overweight group. Nonoverweight patients presented significantly lower leptin concentration (12.7 vs 27.8 ug/l) and higher adiponectin level (38.9 vs 32.5 ng/ml) when compared to overweight patients. The levels of IL-6 and TNFa were higher in the nonoverweight group of patients. Overweight patients also had shorter durations of stay in the hemodialysis program (30.5 vs. 87.6 months).
CONCLUSION: The results of our study indicate that lean hemodialysis patients are more prone to malnutrition and inflammation. The increased levels of leptin and decreased levels of adiponectin in the overweight hemodialysis patients support the idea of a reverse epidemiology phenomenon in this group of patients.
S Małgorzewicz; E Aleksandrowicz-Wrona; A Owczarzak; A Debska-Slizień; B Rutkowski; W Łysiak-Szydłowska
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Publication Detail:
Type:  Journal Article     Date:  2010-01-13
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  20     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Copyright Information:
(c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland.
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MeSH Terms
Adipokines / blood*
Adiponectin / blood
Body Mass Index
Enzyme-Linked Immunosorbent Assay / methods
Inflammation / blood,  complications
Kidney Failure, Chronic / blood*,  complications,  therapy*
Leptin / blood
Malnutrition / blood,  complications
Middle Aged
Nutritional Status*
Overweight / blood,  complications
Renal Dialysis*
Resistin / blood
Reg. No./Substance:
0/Adipokines; 0/Adiponectin; 0/Leptin; 0/Resistin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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