Document Detail

Adipokine levels in the course of mild biliary pancreatitis.
MedLine Citation:
PMID:  23208155     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Obesity markedly increases the risk of severe acute pancreatitis (AP). Several adipokines have been ascribed a role as a predictor of clinical severity in AP. Therefore, the aim of this study was to investigate a possible relationship between leptin and adiponectin and mild biliary AP.
METHODS: We included 24 consecutive patients with mild biliary AP and 24 consecutive healthy age- and sex-matched controls. Clinical severity was classified by the Ranson score. ELISA was used to assess leptin and adiponectin levels on admission and in remission. Complete blood cell counts and other laboratory tests were also performed at baseline and in remission.
RESULTS: Leptin, adiponectin, insulin and HOMA-IR measurements showed no difference in pancreatitis patients both on admission and in remission compared to the control group. No difference was found in leptin, insulin or HOMA-IR levels in the course of pancreatitis. However, adiponectin levels were higher in remission compared to admission.
CONCLUSIONS: Increased adiponectin levels in remission may be an indication of improvement in this condition. Further studies are needed to determine whether adiponectin provides protection from AP.
Selim Demirci; Erdem Akbal; Erdem Koçak; Adnan Taş; Seyfettin Köklü
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Publication Detail:
Type:  Journal Article     Date:  2012-12-03
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  61     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-05-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Acute Disease
Adiponectin / blood*
Body Mass Index
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Insulin / blood
Insulin Resistance
Leptin / blood
Middle Aged
Obesity / blood,  complications,  physiopathology
Pancreatitis / blood*,  etiology,  physiopathology*
Reg. No./Substance:
0/Adiponectin; 0/Insulin; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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