Document Detail

Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis.
MedLine Citation:
PMID:  19565493     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Obesity protects against radiographic joint damage in rheumatoid arthritis (RA) through poorly defined mechanisms. Adipocytokines are produced in adipose tissue and modulate inflammatory responses and radiographic joint damage in animal models. The purpose of this study was to examine the hypothesis that adipocytokines modulate inflammation and radiographic joint damage in patients with RA. METHODS: We compared serum concentrations of leptin, resistin, adiponectin, and visfatin in 167 RA patients and 91 control subjects. The independent association between adipocytokines and body mass index (BMI), measures of inflammation (C-reactive protein [CRP], interleukin-6 [IL-6], and tumor necrosis factor alpha [TNFalpha]), and radiographic joint damage (Larsen score; n = 93 patients) was examined in RA patients by multivariable regression analysis first controlling for age, race, and sex, and then for obesity (BMI) and inflammation (TNFalpha, IL-6, and CRP). RESULTS: Concentrations of all adipocytokines were significantly higher in RA patients than in controls; for visfatin and adiponectin, this association remained significant after adjusting for BMI, inflammation, or both. Visfatin concentrations were associated with higher Larsen scores, and this association remained significant after adjustment for age, race, sex, disease duration, BMI, and inflammation (odds ratio [OR] 2.38 [95% confidence interval (95% CI) 1.32-4.29], P = 0.004). Leptin concentrations showed a positive association with the BMI (rho = 0.58, P < 0.01) and showed a negative association with the Larsen score after adjustment for inflammation (OR 0.32 [95% CI 0.17-0.61], P < 0.001), but not after adjustment for BMI (OR 0.86 [95% CI 0.42-1.73], P = 0.67). CONCLUSION: Concentrations of adipocytokines are increased in patients with RA and may modulate radiographic joint damage. Visfatin is associated with increased, and leptin with reduced, levels of radiographic joint damage.
Young Hee Rho; Joseph Solus; Tuulikki Sokka; Annette Oeser; Cecilia P Chung; Tebeb Gebretsadik; Ayumi Shintani; Theodore Pincus; C Michael Stein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  60     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-09-14     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1906-14     Citation Subset:  AIM; IM    
Vanderbilt University, Nashville, Tennessee 37232-6602, USA.
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MeSH Terms
Adipokines / blood*
Adiponectin / blood
Arthritis, Rheumatoid / blood*,  pathology,  radiography*
Body Mass Index
C-Reactive Protein / metabolism
Case-Control Studies
Cross-Sectional Studies
Foot Joints / pathology,  radiography*
Hand Joints / pathology,  radiography*
Interleukin-6 / blood
Leptin / blood
Middle Aged
Nicotinamide Phosphoribosyltransferase / blood
Obesity / blood
Resistin / blood
Tumor Necrosis Factor-alpha / blood
Grant Support
GM-07569/GM/NIGMS NIH HHS; HL-65082/HL/NHLBI NIH HHS; HL-67964/HL/NHLBI NIH HHS; P60 AR056116-020001/AR/NIAMS NIH HHS; P60-AR-056116/AR/NIAMS NIH HHS; R01 HL065082-09/HL/NHLBI NIH HHS; R01 HL067964-04/HL/NHLBI NIH HHS; T32 GM007569-34/GM/NIGMS NIH HHS; UL1-RR-024975/RR/NCRR NIH HHS
Reg. No./Substance:
0/Adipokines; 0/Adiponectin; 0/Interleukin-6; 0/Leptin; 0/Resistin; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein; EC Phosphoribosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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