Document Detail

Adipocyte morphometric evaluation and angiogenesis in the omentum transposed to the breast: a preliminary study.
MedLine Citation:
PMID:  21484051     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to describe the probable mechanism of the volume increase of laparoscopically harvested omentum flaps used to treat breast deformities.
METHODS: A histological analysis of omentum samples was performed to study the volume increase of laparoscopically harvested omentum flaps. Samples were harvested immediately after the transposition of the omentum from the abdominal cavity to the breast region and during the second surgical procedure for breast symmetrization of eight patients submitted to the transposition of the omentum flap. Changes in the morphometric measurements of the adipocytes (perimeter, diameter, and area), microvascular density (as measured by the CD31 endothelial marker), and immunohistochemical expression of VEGF were documented.
RESULTS: The increases in adipocyte size and microvascular density were statistically significant (P < 0.012). The expression levels of VEGF were lower in the second set of samples when compared to the first set, but the differences were not statistically significant (P < 0.093).
CONCLUSION: These results demonstrate an increase in cellular volume as measured by adipocyte perimeter, diameter, and area. Moreover, the increase in the number of vessels in the second set of samples suggests that neoangiogenesis was stimulated by the initial increase in VEGF expression levels observed in the first set of samples. The increase in VEGF expression in the flap may have been caused by adipocyte hypertrophy resulting from neoangiogenesis.
Sirlei Santos Costa; Rosa Maria Blotta; Luise Meurer; Maria Isabel Albano Edelweiss
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-11-09     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Department of Surgery, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipocytes / cytology*
Body Mass Index
Breast / blood supply,  growth & development*,  surgery
Breast Neoplasms / blood supply,  pathology,  surgery*
Cell Enlargement
Middle Aged
Neovascularization, Physiologic / physiology
Omentum / blood supply,  cytology,  transplantation*
Organ Size
Postoperative Period
Statistics, Nonparametric
Surgical Flaps* / blood supply,  pathology
Time Factors
Vascular Endothelial Growth Factors / physiology*
Young Adult
Reg. No./Substance:
0/Vascular Endothelial Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Strategy for respiratory exercise pattern associated with upper limb movements in COPD patients.
Next Document:  Isokinetic muscle assessment after treatment of pectoralis major muscle rupture using surgical or no...