Document Detail

Adipocyte-derived endotrophin promotes malignant tumor progression.
MedLine Citation:
PMID:  23041627     Owner:  NLM     Status:  MEDLINE    
Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. Here, we have described a cleavage product of the COL6α3 chain, endotrophin (ETP), which serves as the major mediator of the COL6-mediated tumor effects. ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells.
Jiyoung Park; Philipp E Scherer
Related Documents :
10464427 - Necrosis and apoptosis of tumor cells in embolized meningiomas: histopathology and p53,...
15587397 - The relationship of expression of bcl-2, p53, and proliferating cell nuclear antigen (p...
10972857 - Apoptosis and apoptotic-related factors in mucoepidermoid carcinoma of the oral minor s...
11472347 - Flavopiridol circumvents bcl-2 family mediated inhibition of apoptosis and drug resista...
10766177 - Antileukemic activity of flt3 ligand in murine leukemia.
3167857 - Genetic evidence for progressive selection and overgrowth of primary tumors by metastat...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-08
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-01-15     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4243-56     Citation Subset:  AIM; IM    
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adipocytes / metabolism*,  pathology
Cell Communication*
Cell Line, Tumor
Collagen Type VI / metabolism*
Endothelial Cells / metabolism,  pathology
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Macrophages / metabolism,  pathology
Mammary Neoplasms, Animal / metabolism*,  pathology
Neoplasm Metastasis
Neoplasm Proteins / metabolism*
Neovascularization, Pathologic / metabolism*,  pathology
Peptide Fragments / metabolism*
Stromal Cells / metabolism,  pathology
Transforming Growth Factor beta
Grant Support
1P30 CA142543-01/CA/NCI NIH HHS; 1S10RR024757/RR/NCRR NIH HHS; DK081182/DK/NIDDK NIH HHS; P01-DK088761/DK/NIDDK NIH HHS; P30 CA142543/CA/NCI NIH HHS; R01-CA112023/CA/NCI NIH HHS; R01-DK55758/DK/NIDDK NIH HHS; U24 CA126608/CA/NCI NIH HHS
Reg. No./Substance:
0/Collagen Type VI; 0/Neoplasm Proteins; 0/Peptide Fragments; 0/Transforming Growth Factor beta; 0/endotrophin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
Next Document:  Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.