Document Detail


Adhesive and invasive features in gliomas.
MedLine Citation:
PMID:  11087057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aims at the in situ identification of factors mediating glioma cell invasion requiring adhesion, extracellular matrix degradation, and migration. Forty-five gliomas (astrocytomas, glioblastomas, oligodendrogliomas, and mixed gliomas) were investigated for the immunohistochemical expression of the membrane protein CD44s, the basal lamina proteins laminin, collagen IV, and fibronectin, the lectin galectin-3 recognizing tenascin and N-CAM, as well as for the matrix-degrading enzymes metalloproteinases MMP-2, MMP-9, and cathepsin D. Besides vessels expressing basal lamina proteins, tenascin, MMP-2, MMP-9, and galectin-3, tumor cells revealed strong immunoreactivity for CD44s, tenascin, galectin-3, and N-CAM, which was restricted to solid tumor masses. Single invading cells displayed distinct expression of MMP-2 and MMP-9, also found in solid tumor areas, as well as of cathepsin D. Restricted expression of CD44s, galectin-3, tenascin, and N-CAM in solid tumor masses seems to contribute to homotypical tumor cell adhesion. However, switching to an invasive phenotype, single tumor cells lack this expression pattern and acquire degrading and phagocytic activities by expressing cathepsin D, MMP-2, and MMP-9, which are also expressed by solid tumor masses facilitating the loosening and invasion of single neoplastic cells. The blocking of these factors may be of potential benefit in anti-invasive therapy.
Authors:
D S Tews
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  196     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-12     Completed Date:  2001-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  701-11     Citation Subset:  IM    
Affiliation:
Division of Neuropathology, Medical Center, Johannes Gutenberg University, Mainz, Germany. tews@mail.Uni-Mainz.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Brain / pathology,  physiopathology
Brain Neoplasms / pathology*,  physiopathology*
Cell Adhesion
Extracellular Matrix Proteins / metabolism
Glioma / pathology*,  physiopathology*
Humans
Middle Aged
Neoplasm Invasiveness
Reference Values
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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