Document Detail

Adhesion molecules in hematopoietic cells.
MedLine Citation:
PMID:  7527678     Owner:  NLM     Status:  MEDLINE    
Interaction with stromal cells is known to be crucial for growth and differentiation of hematopoietic cells. To characterize adhesion molecules involved in this interaction, we examined adhesion of a panel of lymphoid, myeloid, and mast cell lines with stromal cells. We found that very late antigen-4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) were major adhesion molecules in lymphoid and myeloid cells, whereas myeloma cells adhered to stromal cells through hyaluronate. We investigated regulation of VLA-4 during differentiation of myeloid cells using a neutrophil precursor cell line, L-G3. Differentiation of neutrophils induced by granulocyte colony-stimulating factor was accompanied with down-regulation of VLA-4. Induced L-G3 cells adhered to stromal cells in proportion to the expression of VLA-4. Mast cells used two mechanisms to adhere to fibroblasts and stromal cells. They adhered to fibronectin through VLA-5 when stimulated with steel factor and also directly to membrane-anchored steel factor through c-kit.
T Kinashi; T A Springer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood cells     Volume:  20     ISSN:  0340-4684     ISO Abbreviation:  Blood Cells     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-19     Completed Date:  1995-01-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7513567     Medline TA:  Blood Cells     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-44     Citation Subset:  IM    
Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115.
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MeSH Terms
Cell Adhesion / physiology
Cell Adhesion Molecules / blood*,  physiology
Cell Differentiation / physiology
Cell Line
Down-Regulation / physiology
Hematopoietic Cell Growth Factors / physiology
Hematopoietic Stem Cells / cytology*
Mice, Inbred BALB C
Neutrophils / cytology
Proto-Oncogene Proteins / physiology
Proto-Oncogene Proteins c-kit
Receptor Protein-Tyrosine Kinases / physiology
Receptors, Colony-Stimulating Factor / physiology
Receptors, Very Late Antigen / isolation & purification,  metabolism
Stem Cell Factor
Stromal Cells / cytology
Tumor Cells, Cultured
Vascular Cell Adhesion Molecule-1
Grant Support
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Hematopoietic Cell Growth Factors; 0/Proto-Oncogene Proteins; 0/Receptors, Colony-Stimulating Factor; 0/Receptors, Very Late Antigen; 0/Stem Cell Factor; 0/Vascular Cell Adhesion Molecule-1; EC Proteins c-kit; EC Protein-Tyrosine Kinases

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