Document Detail

Adhesion molecules, activin and inhibin--candidates for the biochemical prediction of hypertensive diseases in pregnancy?
MedLine Citation:
PMID:  12898146     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of the prospective study was to compare standard parameters as Doppler ultrasound and 24-h blood pressure measurement with possible maternal serological markers regarding their prognostic value in predicting hypertensive diseases in pregnancy. MATERIALS: Twenty-four-hour blood pressure measurement was performed before and after 32+0 gestational week in 57 pregnant women with either chronic hypertension ( n=13), preeclampsia ( n=21), pregnancy-induced hypertension (PIH; n=12) or normotension ( n=11). Blood samples were taken and the concentrations of soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), activin A and inhibin A were determined as well as serum uric acid, creatinine, total serum protein and serum albumin. Doppler ultrasound of the uterine arteries was examined before 32+0 gestational week in the same patients. For the statistical evaluation Kruskal-Wallis-Test and Mann-Whitney-U-Test were performed. Differences in the predictive value were evaluated by receiver-operating characteristics. RESULTS: VCAM-1 was significantly elevated in women developing hypertensive diseases as compared to normotensive women (preeclampsia: p<0.001; PIH: p<0.05; chronic hypertension: p<0.001). In early pregnancy activin A and inhibin A were significantly higher in preeclamptic patients than in the other groups (activin A: normotension: p<0.005; PIH: p<0.001; chronic hypertension: p<0.005) (inhibin A: normotension: p<0.005; PIH: p<0.001; chronic hypertension: p<0.01), thus suggesting them to be specific markers for the development of preeclampsia. Mean arterial pressure was significantly elevated in preeclampsia ( p<0.001) and chronic hypertension ( p<0.005) as compared to normotensives. CONCLUSION: Twenty-four-hour blood pressure monitoring with determination of mean arterial pressure and measurement of VCAM-1, activin A and inhibin A as serum parameters can be suggested as useful tests in the specific prediction of different types of hypertensive diseases in pregnancy.
Claudia G Hanisch; Kerstin A Pfeiffer; Harald Schlebusch; Jan Schmolling
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-07-25
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  270     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2005-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  110-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Hospital, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany.
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MeSH Terms
Activins / blood*
Biological Markers / blood
Blood Pressure / physiology
Blood Pressure Monitoring, Ambulatory
Enzyme-Linked Immunosorbent Assay
Hypertension / blood,  diagnosis*
Hypertension, Pregnancy-Induced / blood,  diagnosis
Inhibin-beta Subunits / blood*
Inhibins / blood*
Intercellular Adhesion Molecule-1 / blood
Pre-Eclampsia / blood,  diagnosis
Pregnancy Complications, Cardiovascular / blood,  diagnosis*
Prospective Studies
ROC Curve
Sensitivity and Specificity
Vascular Cell Adhesion Molecule-1 / blood*
Reg. No./Substance:
0/Biological Markers; 0/Vascular Cell Adhesion Molecule-1; 0/activin A; 0/inhibin A; 104625-48-1/Activins; 126547-89-5/Intercellular Adhesion Molecule-1; 57285-09-3/Inhibins; 93443-12-0/Inhibin-beta Subunits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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